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Keyes KT1, Xu J, Long B, Zhang C, Hu Z, Ye Y.
Am J Physiol Heart Circ Physiol. 2010 Apr;298(4):H1198-208. doi: 10.1152/ajpheart.00915.2009. Epub 2010 Jan 22.
Phosphoinositide 3-kinase (PI3K) mediates myocardium protective signaling through phosphorylation of phosphatidylinositol (Ptdins) to produce Ptdins(3,4,5)P(3). Lipid phosphatase and tensin homolog on chromosome 10 (PTEN) antagonizes PI3K activity by dephosphorylating Ptdins(3,4,5)P(3); therefore, the inhibition of PTEN enhances PI3K/Akt signaling and could prevent myocardium from ischemia-reperfus ... Read MoreProducts
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