Ubenimex

• Catalog Number: ACM58970766
• Product Name: Ubenimex
• CAS: 58970-76-6
• Category: Main Products
• Description: Ubenimex (INN), also known more commonly as bestatin, is a competitive, reversible protease inhibitor. It is an inhibitor of arginyl aminopeptidase (aminopeptidase B), leukotriene A4 hydrolase (a zinc metalloprotease that displays both epoxide hydrolase and aminopeptidase activities), alanyl aminopeptidase (aminopeptidase M/N), leucyl/cystinyl aminopeptidase (oxytocinase/vasopressinase), and membrane dipeptidase (leukotriene D4 hydrolase). It is being studied for use in the treatment of acute myelocytic leukemia. It is derived from Streptomyces olivoreticuli. Ubenimex has been found to inhibit the enzymatic degradation of oxytocin, vasopressin, enkephalins, and various other peptides and compounds.
• Synonyms: 3-(r)-amino-2-(s)-hydroxy-4-phenylbutanoyl-(s)-leucine;n-(3-amino-2-hydroxy-1-oxo-4-phenylbutyl)-,(s-(r*,s*))-l-leucin;nk421;UBENIMEX;N-[(2S,3R)-3-AMINO-2-HYDROXY-1-OXO-4-PHENYLBUTYL]-L-LEUCINE;N-((2S,3R)-3-AMINO-2-HYDROXY-4-PHENYLBUTYRYL)-L-LEUCINE;[(2S,3R)-3-AMINO-2-HYDROXY-4-PHENYLBUTYRYL]-L-LEUCINE;[(2S,3R)-3-AMINO-2-HYDROXY-4-PHENYLBUTANOYL]-LEU
• IUPAC Name: (2S)-2-[[(2S,3R)-3-amino-2-hydroxy-4-phenylbutanoyl]amino]-4-methylpentanoicacid
• Molecular Weight: 308.37
• Molecular Formula: C16H24N2O4
• Canonical SMILES: CC(C)CC(C(=O)O)NC(=O)C(C(CC1=CC=CC=C1)N)O
• InChI Key: VGGGPCQERPFHOB-RDBSUJKOSA-N
• Boiling Point: 604.7ºC at 760 mmHg
• Melting Point: 245ºC
• Flash Point: 319.5ºC
• Density: 1.197 g/cm³
• Appearance: White crystalline powder
• EC Number: 261-529-2
• Exact Mass: 308.17400
• LogP: 1.62400
• PSA: 112.65
• Refractive Index: 1.557
• Safety Description: 22-24/25
• Stability: Stable at normal temperatures and pressures.
• Storage Conditions: 2-8ºC
• WGK Germany: 3