Sulfamerazine sodium salt

• CAS: 127-58-2
• Catalog Number: ACM127582
• Category: Main Products
• Molecular Weight: 286.29
• Molecular Formula: C11H11N4O2SNa
• Appearance: White to Very Lt. Yellow Powder

Case Study

Crystallization and Transformation Studies of Sulfamethazine Polymorphs

Zhang, Geoff GZ, et al. Journal of pharmaceutical sciences, 2002, 91(4), 1089-1100.

Bulk powders of sulfamethazine (SMZ) polymorph II with narrow particle size distribution were prepared and two known sulfamethazine polymorphs I and II were physically characterized. Sulfamethazine sodium salt (NaSMZ) was used to achieve rapid crystallization of SMZ from water. The results showed that the two polymorphs were enantiomers with slow kinetics of interconversion. The thermodynamic transition temperatures were between 51 and 54°C, with polymorph II being stable at lower temperatures.
NaSMZ used in the preparation of polymorph II
· SMZ polymorph II can be obtained by recrystallization from a solution prepared by suspending an excess of polymorph I in acetonitrile. In addition, when the corresponding seed crystals are available, a large amount of polymorph II can be more efficiently crystallized from acetonitrile by a slurry process.
· During the recrystallization process, rapid crystallization of SMZ from water was achieved by adding hydrochloric acid to an aqueous solution of SMZ sodium salt. The crystals thus obtained were washed thoroughly with distilled water to remove residual electrolytes. This method is called "sodium salt acidification".

Custom Reviews

August 04, 2023

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Convenient to use
The use effect of sulfamerazine sodium salt is very good, and the packaging is easy to be reused.

Custom Q&A

What is the molecular formula of Sulfamerazine sodium salt?

The molecular formula of Sulfamerazine sodium salt is C11H11N4NaO2S.

What are some synonyms for Sulfamerazine sodium salt?

Some synonyms for Sulfamerazine sodium salt include SULFAMERAZINE SODIUM, Sodium sulfamerazine, Soluble sulfamerazine, and Solumedine.

What is the IUPAC name of Sulfamerazine sodium salt?

The IUPAC name of Sulfamerazine sodium salt is sodium;(4-aminophenyl)sulfonyl-(4-methylpyrimidin-2-yl)azanide.

What is the InChIKey of Sulfamerazine sodium salt?

The InChIKey of Sulfamerazine sodium salt is BSFJGCCAXDCMOX-UHFFFAOYSA-N.

What is the chemical safety information of Sulfamerazine sodium salt?

Sulfamerazine sodium salt is listed as an irritant.

What is the CAS number of Sulfamerazine sodium salt?

The CAS number of Sulfamerazine sodium salt is 127-58-2.

What is the structure of Sulfamerazine sodium salt?

The structure of Sulfamerazine sodium salt is depicted in the provided images.

What is the purpose of Sulfamerazine sodium salt?

Sulfamerazine sodium salt is a long-acting sulfanilamide antibacterial agent.

Is Sulfamerazine sodium salt soluble?

Yes, Sulfamerazine sodium salt is soluble.

Can you provide any other names or identifiers for Sulfamerazine sodium salt?

Some other names for Sulfamerazine sodium salt include Sulfamerazine sodique, Sulfamerazine Sodium Injection, and Sodium derivate of N1-(4-methyl-2-pyrimidinyl)sulfanilamide.