sucrose palmitate

• CAS: 26446-38-8
• Catalog Number: ACM26446388
• Category: Main Products
• Molecular Weight: 580.70
• Molecular Formula: C28H52O12
• Synonyms: Ryoto Sugar Ester P-1670
• Flash Point: 375.4°C
• Solubility: water, 0.2706 mg/L @ 25 °C (est)
• Appearance: White to off-white powder
• Assay: 0.98
• EC Number: 247-706-7
• MDL Number: MFCD00047545
• Packaging: 1 kg
• Refractive Index: 1.562

Case Study

Sucrose Palmitate as a Bio-Filler for Enhancing the Thermal Stability of Poly(Lactic Acid) Biocomposites for Food Packaging Applications

Valapa R, et al. International Journal of Biological Macromolecules, 2014, 65, 275-283.

Sucrose palmitate (SP) is explored as a novel bio-filler in poly(lactic acid) (PLA) biocomposites, aiming to enhance their thermal stability for food packaging applications. The integration of SP into the PLA matrix effectively decelerates the thermal degradation rate, as evidenced by thermogravimetric analysis (TGA). Up to a 5 wt% loading of SP, the thermal degradation profile of the PLA composites remains similar to pure PLA, with no significant shift in the maximum degradation temperature (Tmax), indicating SP's role as a protective barrier. However, at higher filler concentrations (10 wt%), Tmax shifts to a lower temperature (324 °C), likely due to the increased acidic sites and enhanced degradation rate. Differential scanning calorimetry (DSC) analysis further supports the presence of a unimodal melting peak, confirming the α-crystalline form of PLA. The activation energies of thermal degradation, calculated using Flynn-Wall-Ozawa and Kissinger methods, provide insights into the degradation kinetics of PLA-SP composites. This case study demonstrates sucrose palmitate's potential as an effective thermal stabilizer in biocomposite materials, making it a promising candidate for enhancing the performance of PLA-based food packaging products.

Sucrose Palmitate (SP) as a Plasticizer in Poly(Lactic Acid) (PLA) Nanocomposite Films

Valapa R b, et al. International Journal of Biological Macromolecules, 2016, 89, 70-80.

Sucrose palmitate (SP) is utilized as a plasticizing agent in the preparation of poly(lactic acid) (PLA) nanocomposite films. In a solution-casting approach, PLA was dissolved in chloroform, followed by the addition of SP, with 5 wt% of sucrose palmitate relative to PLA. The PLA-SP mixture was cast onto a Teflon petri plate and dried under ambient conditions before being vacuum-dried at 40°C. The resulting nanocomposite film exhibited a thickness of approximately 60 μm, and further characterization confirmed the structural integrity of the composite. The addition of sucrose palmitate enhances the film's flexibility and processability, positioning PLA-SP composites as a promising alternative for environmentally friendly packaging materials.

Sucrose Palmitate as a Stabilizer in the Formulation of Inhalable Rifampicin-Loaded PLGA Microspheres

Diab R, et al. International Journal of Pharmaceutics, 2012, 436(1-2), 833-839.

Sucrose palmitate (SP) has been utilized as an effective stabilizer in the preparation of rifampicin-loaded poly(lactic-co-glycolic acid) (PLGA) microspheres (RIF-MS) through the oil-in-water (O/W) emulsion-solvent evaporation method.
In brief, the solutions of rifampicin (RIF) and PLGA in dichloromethane, chloroform, or a 1:5 mixture of chloroform and dichloromethane, forming the organic phase, were emulsified in a 50 ml aqueous sucrose palmitate solution for 5 minutes using a Polytron® Homogenizer PT 3100D set at 10,000 rpm, equipped with a 12-mm diameter aggregate-dispersing rotor-stator. Following the formation of the O/W emulsion, the organic solvents were evaporated by either rotary evaporation under reduced pressure (room temperature, 40 mbar) for 15 minutes or by magnetic stirring at 500 rpm at atmospheric pressure for 3 hours. The resulting RIF-MS were then separated by centrifugation at 280 × g for 15 minutes, followed by three washes with purified water to remove any residual surfactant and unencapsulated drug. Finally, the recovered microspheres were freeze-dried using a freeze-drier.

Study on sucrose palmitate reinforced nanofilms

Valapa, Ravi Babu, G. Pugazhenthi, and Vimal Katiyar.Journal of Applied Polymer Science 132.3 (2015).

Environmental issues related to petroleum-based polymers have begun to give increasing importance to the use of sustainable polylactic acid (PLA)-based packaging. Attempts have been made to use food additive sucrose palmitate (SP) as an eco-friendly filler to fabricate PLA-based bionanocomposites. FTIR analysis elucidated the presence of hydrogen bonding and intermolecular interactions between PLA and the reinforcements. The PLASP bionanocomposite films confirmed the best positive impact on the oxygen barrier, with a 69% reduction in oxygen permeability compared to neat PLA.
0.95 g of PLA was mixed in 50 mL of chloroform and subsequently stirred for 2 h to completely dissolve the PLA. Similarly, different concentrations of sucrose palmitate were dispersed in chloroform and stirred continuously for 1 h. Subsequently, the solution containing the dispersed SP was transferred to the PLA-chloroform mixture under vigorous stirring. The PLA-SP solution was cast on a polytetrafluoroethylene culture plate and further dried at room temperature for 24 h. The dried composite film was carefully peeled off from the rock plate. The resulting films were finally oven-dried at 40 °C for 12 h under vacuum and stored in sealed bags at room temperature for further characterization.

Effect of sucrose palmitate on mucoadhesive properties

Kelemen, András, et al. Molecules 25.22 (2020): 5248.

Sucrose palmitate (SP) was used as a possible permeation enhancer for oral use. Films containing SP were prepared at different temperatures, different concentrations of SP and different lengths of hydroxypropyl methylcellulose (HPMC) chains. Mechanical, structural and in vitro mucoadhesive properties of films containing SP were investigated. Structural analysis of the films was performed using positron annihilation lifetime spectroscopy (PALS) and X-ray powder diffraction (XRPD).
Sucrose palmitate (SP) was added to the polymer solution at concentrations of 1 and 2 w/w%. The HLB value of SP is 16. Distilled water was used as a solvent for the polymer solution. Solvent casting method was used to prepare the film on the surface of polytetrafluoroethylene. This method is widespread and easily applicable to the production of oral films. Two different temperatures were used for solution preparation and drying: 25 °C and 50 °C, with a relative humidity (RH) of 65% for 24 h.

Sucrose palmitate for enhancing the stability of a novel lipid nanoemulsion

Takegami, Shigehiko, et al. Chemical and Pharmaceutical Bulletin 56.8 (2008): 1097-1102.

A novel lipid nanoemulsion (LNE) was prepared from soybean oil and phosphatidylcholine (PC) using two cosurfactants, sodium palmitate (PA) to reduce the droplet size and sucrose palmitate (SP) for stability enhancement. The results showed that PA/SP/PC (1/4/10)-LNE could maintain an average droplet size of around 50 nm for 12 months. In saline solution, the average droplet size could be maintained within 100 nm even after 24 h. The P nuclear magnetic resonance line width of LNE was measured, indicating that flocculation was slightly formed in LNE depending on the storage period.
The amounts of soybean oil (SO) and phosphatidylcholine (PC) used in the LNE preparation were given by theoretical calculations based on the assumption that the lipid particles were spheres with a diameter of 50 nm. To a mixture of SO, PC, and glycerol (2.2 (w/v)%) in 30 ml of deionized distilled water, different amounts of sodium palmitate and sucrose palmitate, cholesterol, Tween 80, or sucrose were added and placed in a constant temperature water bath. The sonication was repeated for 3 min at 3 min intervals. The obtained LNEs were then centrifuged at 2000 g to eliminate the precipitate from the sonication tip. All prepared LNEs were stored in airtight, light-resistant glass containers at room temperature under nitrogen atmosphere.

Custom Q&A

What is the molecular formula of sucrose palmitate?

The molecular formula of sucrose palmitate is C28H52O12.

What are the synonyms of sucrose palmitate?

The synonyms of sucrose palmitate are Sucrose palmitate (VAN), EINECS 247-706-7, NSC 192746, and Sucrose palmitate [NF].

What is the molecular weight of sucrose palmitate?

The molecular weight of sucrose palmitate is 580.7 g/mol.

When was sucrose palmitate created?

Sucrose palmitate was created on August 8, 2005.

What is the IUPAC name of sucrose palmitate?

The IUPAC name of sucrose palmitate is [(2S,3R,4S,5S,6R)-2-[(2S,3S,4S,5R)-3,4-dihydroxy-2,5-bis(hydroxymethyl)oxolan-2-yl]-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl] hexadecanoate.

What is the InChI of sucrose palmitate?

The InChI of sucrose palmitate is InChI=1S/C28H52O12/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-21(32)40-28(26(37)24(35)22(33)19(16-29)39-28)27(18-31)25(36)23(34)20(17-30)38-27/h19-20,22-26,29-31,33-37H,2-18H2,1H3/t19-,20-,22-,23-,24+,25+,26-,27+,28+/m1/s1.

What is the InChIKey of sucrose palmitate?

The InChIKey of sucrose palmitate is ZPVGIKNDGJGLCO-VGAMQAOUSA-N.

What is the canonical SMILES of sucrose palmitate?

The canonical SMILES of sucrose palmitate is CCCCCCCCCCCCCCCC(=O)OC1(C(C(C(C(O1)CO)O)O)O)C2(C(C(C(O2)CO)O)O)CO.

What is the CAS number of sucrose palmitate?

The CAS number of sucrose palmitate is 26446-38-8.

What is the XLogP3-AA value of sucrose palmitate?

The XLogP3-AA value of sucrose palmitate is 3.2.