α-Zingiberene

• CAS: 495-60-3
• Catalog Number: ACM495603
• Category: Main Products
• Molecular Weight: 204.35
• Molecular Formula: C15H24
• Synonyms: (5R)-5-[(1S)-1,5-Dimethyl-4-hexen-1-yl]-2-methyl-1,3-cyclohexadiene
• Appearance: Colourless oil

Case Study

α-Zingiberene as a Non-Zinc-Binding HDAC1 Inhibitor for Neuropathic Pain Management

Borgonetti V, et al. Phytomedicine, 2023, 111, 154670.

α-Zingiberene has been identified as a selective histone deacetylase 1 (HDAC1) inhibitor with potential therapeutic applications in trauma-induced neuropathic pain. Unlike traditional zinc-binding HDAC inhibitors, α-zingiberene operates through a non-zinc-dependent mechanism, enhancing selectivity and reducing off-target effects. In vitro studies demonstrated its potent inhibitory activity on HDAC1, with an IC50 of 2.3 ± 0.1 µM, while in vivo administration effectively alleviated neuropathic pain symptoms, including thermal hyperalgesia and mechanical allodynia. Mechanistically, α-zingiberene downregulates HDAC1 expression in spinal cord microglia, thereby modulating neuroinflammatory pathways associated with peripheral neuropathy. Its non-zinc-binding inhibition strategy offers a promising alternative to conventional HDAC inhibitors, improving safety and therapeutic efficacy in neurodegenerative and pain-related disorders.