The formation of carbon-carbon double (C=C) and triple (C≡C) bonds is fundamental to organic chemistry, enabling the creation of unsaturated frameworks essential for pharmaceuticals, polymers, and advanced materials. From stereoselective olefination to alkyne cross-coupling, name reactions pioneered by leading chemists provide robust tools for these transformations. At Alfa Chemistry, we equip researchers with premium reagents, catalysts, and technical insights to master these pivotal methodologies. Explore key reactions for building C=C and C≡C bonds below.
Key C＝C & C≡C Bond-Forming Name Reactions
Bamford-Stevens Reaction
Generates alkenes via thermal decomposition of tosylhydrazones derived from ketones, offering a route to trisubstituted olefins.
Burgess Dehydrating Reagent
A sulfonyl triazine reagent that dehydrates alcohols to alkenes under mild, non-acidic conditions, ideal for acid-sensitive substrates.
Chugaev Reaction
Thermal elimination of xanthate esters to form alkenes, providing stereoselective control in cyclic systems.
Cope Elimination Reaction
Converts amine oxides to alkenes through a concerted thermal process, widely used in alkaloid synthesis.
Corey-Fuchs Reaction
Transforms aldehydes into terminal alkynes via a two-step dibromoolefination and dehydrohalogenation sequence.
Corey-Winter Reaction
Converts 1,2-diols to alkenes using thiocarbonyldiimidazole, preserving stereochemistry in cyclic systems.
Grubbs Reaction
A ruthenium-catalyzed olefin metathesis enabling versatile C＝C bond reorganization in polymer and natural product synthesis.
Horner-Wadsworth-Emmons Reaction
Phosphonate esters condense with aldehydes to form trans-alkenes with high stereoselectivity, critical in drug design.
Julia-Kocienski Olefination
Links sulfones with carbonyl compounds to generate alkenes, adaptable to complex fragment couplings.
Knoevenagel Condensation
Base-catalyzed coupling of active methylene compounds with aldehydes, forming α,β-unsaturated carbonyls for agrochemicals.
McMurry Olefination
Reductive coupling of ketones or aldehydes using low-valent titanium to form symmetrical or conjugated alkenes.
