Cyclization reactions are pivotal in constructing cyclic frameworks—ranging from aromatic carbocycles to bioactive heterocycles—found in pharmaceuticals, agrochemicals, and advanced materials. By leveraging targeted bond formation between functional groups, various name reactions enable precise control over ring size, stereochemistry, and electronic properties. At Alfa Chemistry, we provide specialized reagents, catalysts, and technical expertise to empower researchers in mastering these transformative methodologies. Explore key cyclization name reactions below to unlock new dimensions in molecular design.
Core Cyclization Name Reactions
Bergman Cyclization
Thermally activates enediynes to generate para-benzyne diradicals, enabling DNA-cleaving agents for anticancer drug development.
Bucherer-Bergs Reaction
Condenses carbonyl compounds with cyanide and ammonium carbonate to synthesize hydantoins, foundational in heterocyclic chemistry.
Corey-Chaykovsky Reaction
Utilizes sulfonium or sulfoxonium ylides to form epoxides, cyclopropanes, or aziridines, critical for strained ring systems in drug intermediates.
Dieckmann Condensation
Intramolecular ester condensation catalyzed by base to yield cyclic β-keto esters, widely used in natural product total synthesis.
Diels-Alder Cycloaddition Reaction
[4+2] Cycloaddition of dienes and dienophiles forms six-membered rings, a cornerstone in polymer and terpene synthesis.
Feist-Bénary Reaction
Couples α-haloketones with enolates to synthesize furan derivatives, essential for agrochemicals and bioactive heterocycles.
