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Home > Publication > Cobalt- versus ruthenium-catalyzed Alder-ene reaction for the synthesis of credneramide A and B.

Cobalt- versus ruthenium-catalyzed Alder-ene reaction for the synthesis of credneramide A and B.

Erver F1, Hilt G.

J Org Chem. 2012 Jun 1;77(11):5215-9. doi: 10.1021/jo3007896. Epub 2012 May 11.

The first synthesis of the natural products credneramide A and B was accomplished by utilizing Alder-ene reactions between a terminal alkene and an internal alkyne to generate the rather uncommon 1,4-diene substructure of these compounds. Moreover, two different short linear sequences toward these targets are evaluated using either a cobalt-catalyzed Alder-ene reaction of 1-chloropent-1-yne or a ruthenium-catalyzed Alder-ene reaction of 1-trimethylsilyl-1-pentyne with 5-hexenoic acid derivatives in the key step transformation. In addition, saponification of the primary Alder-ene product derived from the cobalt-catalyzed Alder-ene reaction led to credneric acid, the biological precursor of both natural products.

Chemicals Used in the Paper:

Catalog Number Product Name Structure CAS Number Price
ACM18270172 1-(Trimethylsilyl)-1-pentyne 1-(Trimethylsilyl)-1-pentyne 18270-17-2 Price

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Email:
Tel:1-201-478-8534
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Fax: 1-516-927-0118
Address: 2200 Smithtown Avenue, Room 1 Ronkonkoma, NY 11779-7329 USA