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Home > Publication > Conjugation of monocarboxybetaine molecules on Amino-Poly-p-xylylene films to reduce protein adsorption and cell adhesion

Conjugation of monocarboxybetaine molecules on Amino-Poly-p-xylylene films to reduce protein adsorption and cell adhesion

Chien H W, Keng M C, Wang M J, et al.

Langmuir, 2014, 30(47): 14257-14262.

A surface that resists protein adsorption and cell adhesion is highly desirable for many biomedical applications such as blood-contact devices and biosensors. In this study, the authors fabricated a carboxybetaine-containing surface and evaluated its antifouling efficacy. First, an amine-containing substrate was created by chemical vapor deposition of 4-aminomethyl-p-xylylene-co-p-xylylene (Amino-PPX). Aldehyde-ended carboxybetaine molecules were synthesized and conjugated onto Amino-PPX. The carboxybetaine-PPX surface greatly reduced protein adsorption and cell adhesion. The attachment of L929 cells on the carboxybetaine-PPX surface was reduced by 87% compared to the cell adhesion on Amino-PPX. Furthermore, RGD peptides could be conjugated on carboxybetaine-PPX to mediate specific cell adhesion. In conclusion, the authors demonstrate that a surface decoration with monocarboxybetaine molecules is useful for antifouling applications.

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Email:
Tel:1-201-478-8534
1-516-662-5404
Fax: 1-516-927-0118
Address: 2200 Smithtown Avenue, Room 1 Ronkonkoma, NY 11779-7329 USA