CONTACT US

Email: info@alfa-chemistry.com
Tel:1-201-478-8534
1-516-662-5404
Fax: 1-516-927-0118
Address: 2200 Smithtown Avenue, Room 1 Ronkonkoma, NY 11779-7329 USA

For product inquiries, please use our online system or send an email to
inquiry@alfa-chemistry.com

chemistry partner
Home > Publication > Polyunsaturated fatty acids ameliorate aging via redox-telomere-antioncogene axis.

Polyunsaturated fatty acids ameliorate aging via redox-telomere-antioncogene axis.

Chen J1, Wei Y1, Chen X1, Jiao J2, Zhang Y1.

Oncotarget. 2016 Dec 26. doi: 10.18632/oncotarget.14236. [Epub ahead of print]

Polyunsaturated fatty acids (PUFA), a group of nourishing and health-promoting nutrients, ameliorate age-related chronic diseases. However, how PUFA especially n-3 PUFA exert anti-aging functions remains poorly understood. Here we link fish oil, docosahexaenoic acid (DHA) and arachidonic acid (AA) to the aging etiology via a redox-telomere-antioncogene axis based on D-galactose-induced aging mice. Both fish oil and PUFA enhanced hepatic superoxide dismutase (SOD) and catalase activities and cardiac SOD activities within the range of 18%-46%, 26%-65% and 19%-58%, respectively, whereas reduced cerebral monoamine oxidase activity, plasma F2-isoprostane level and cerebral lipid peroxidation level by 56%-90%, 20%-79% and 16%-54%, respectively. Thus, PUFA improve the in vivo redox and oxidative stress induced aging process, which however does not exhibit a dose-dependent manner. Notably, both PUFA and fish oil effectively inactivated testicular telomerase and inhibited c-Myc-mediated telomerase reverse transcriptase expression, whereas n-3 PUFA rather than n-6 PUFA protected liver and testes against telomere shortening within the range of 13%-25% and 25%-27%, respectively. Therefore, n-3 PUFA may be better at inhibiting the DNA damage induced aging process. Surprisingly, only DHA significantly suppressed cellular senescence pathway evidenced by testicular antioncogene p16 and p53 expression. This work provides evident support for the crosstalk between PUFA especially n-3 PUFA and the aging process via maintaining the in vivo redox homeostasis, rescuing age-related telomere attrition and down-regulating the antioncogene expression.

Chemicals Related in the Paper:

Catalog Number Product Name Structure CAS Number Price
ACM100124069 Dibenzofuran-4-boronic acid Dibenzofuran-4-boronic acid 100124-06-9 Price
ACM1003043342 2-Bromo-3-methylpyridine-5-boronic acid 2-Bromo-3-methylpyridine-5-boronic acid 1003043-34-2 Price
ACM1003043400 2-Chloro-3-methylpyridine-5-boronic acid 2-Chloro-3-methylpyridine-5-boronic acid 1003043-40-0 Price
ACM100622342 9-Anthraceneboronic acid 9-Anthraceneboronic acid 100622-34-2 Price
ACM10365987 3-Methoxyphenylboronic acid 3-Methoxyphenylboronic acid 10365-98-7 Price
ACM10443659 2-Bromoacrylic acid 2-Bromoacrylic acid 10443-65-9 Price
ACM105365513 4-Butoxyphenylboronic acid 4-Butoxyphenylboronic acid 105365-51-3 Price
ACM108847207 4-Dibenzothienylboronic acid 4-Dibenzothienylboronic acid 108847-20-7 Price
ACM108847763 Thianthren-1-ylboronic acid Thianthren-1-ylboronic acid 108847-76-3 Price
ACM110802841 Chloroiridic acid Chloroiridic acid 110802-84-1 Price
ACM120153084 4-Carboxy-3-fluorophenylboronic acid 4-Carboxy-3-fluorophenylboronic acid 120153-08-4 Price
ACM121219123 4-Pentylbenzeneboronic acid 4-Pentylbenzeneboronic acid 121219-12-3 Price
ACM122775353 3,4-Dimethoxyphenylboronic acid 3,4-Dimethoxyphenylboronic acid 122775-35-3 Price
ACM127972025 5-Formyl-2-methoxyphenylboronic acid 5-Formyl-2-methoxyphenylboronic acid 127972-02-5 Price
ACM128796394 4-(Trifluoromethyl)phenylboronic acid 4-(Trifluoromethyl)phenylboronic acid 128796-39-4 Price
ACM149557186 3-Propoxyphenylboronic acid 3-Propoxyphenylboronic acid 149557-18-6 Price
ACM134150019 4-Propylphenylboronic acid 4-Propylphenylboronic acid 134150-01-9 Price
ACM136496725 4-Carboxy-3-chlorophenylboronic acid 4-Carboxy-3-chlorophenylboronic acid 136496-72-5 Price
ACM139911276 4-Fluoro-3-methylphenylboronic acid 4-Fluoro-3-methylphenylboronic acid 139911-27-6 Price
ACM139911298 4-Fluoro-2-methylphenylboronic acid 4-Fluoro-2-methylphenylboronic acid 139911-29-8 Price
ACM148839332 5-Chloro-2-methylphenylboronic acid 5-Chloro-2-methylphenylboronic acid 148839-33-2 Price
ACM15016430 3-Vinylphenylboronic acid 3-Vinylphenylboronic acid 15016-43-0 Price
ACM150255962 3-Cyanophenylboronic acid 3-Cyanophenylboronic acid 150255-96-2 Price
ACM153624465 4-Isopropoxyphenylboronic acid 4-Isopropoxyphenylboronic acid 153624-46-5 Price
ACM156641984 6-Methoxy-2-naphthaleneboronic acid 6-Methoxy-2-naphthaleneboronic acid 156641-98-4 Price
ACM156682541 3-Benzyloxybenzeneboronic acid 3-Benzyloxybenzeneboronic acid 156682-54-1 Price
ACM15872421 4-N-Heptyloxybenzoic acid 4-N-Heptyloxybenzoic acid 15872-42-1 Price
ACM15872443 4-N-Undecyloxybenzoic acid 4-N-Undecyloxybenzoic acid 15872-44-3 Price
ACM160591913 4-Chloro-2-fluorophenylboronic acid 4-Chloro-2-fluorophenylboronic acid 160591-91-3 Price
ACM16152515 4-Isopropylphenylboronic acid 4-Isopropylphenylboronic acid 16152-51-5 Price
ACM162607183 5-Chlorothiophene-2-boronic acid 5-Chlorothiophene-2-boronic acid 162607-18-3 Price
ACM163105893 2-Methoxy-5-pyridineboronic acid 2-Methoxy-5-pyridineboronic acid 163105-89-3 Price
ACM163517622 5-Fluoro-2-methylphenylboronic acid 5-Fluoro-2-methylphenylboronic acid 163517-62-2 Price
ACM159239335 12-Mercaptododecylphosphonic acid 12-Mercaptododecylphosphonic acid 159239-33-5 Price
ACM166744781 4-Benzyloxy-2-fluorophenylboronic acid 4-Benzyloxy-2-fluorophenylboronic acid 166744-78-1 Price
ACM139301272 4-(Trifluoromethoxy)phenylboronic acid 4-(Trifluoromethoxy)phenylboronic acid 139301-27-2 Price
ACM141981648 2-Anthraceneboronic acid 2-Anthraceneboronic acid 141981-64-8 Price
ACM144432859 3-Chloro-4-fluorophenylboronic acid 3-Chloro-4-fluorophenylboronic acid 144432-85-9 Price
ACM145240284 4-Butylphenylboronic acid 4-Butylphenylboronic acid 145240-28-4 Price
ACM146631007 4-Benzyloxyphenylboronic acid, pinacol ester 4-Benzyloxyphenylboronic acid, pinacol ester 146631-00-7 Price
ACM151169674 4-Chloro-3-nitrophenylboronic acid 4-Chloro-3-nitrophenylboronic acid 151169-67-4 Price
ACM151169754 3,4-Dichlorophenylboronic acid 3,4-Dichlorophenylboronic acid 151169-75-4 Price
ACM156545072 3,5-Difluorophenylboronic acid 3,5-Difluorophenylboronic acid 156545-07-2 Price
ACM162101317 2-Fluoro-4-methoxyphenylboronic acid 2-Fluoro-4-methoxyphenylboronic acid 162101-31-7 Price
ACM16419606 2-Methylphenylboronic acid 2-Methylphenylboronic acid 16419-60-6 Price
ACM1951388 2-Methoxyisophthalic acid 2-Methoxyisophthalic acid 1951-38-8 Price
ACM23341131 5-Cyanoisophthalic acid 5-Cyanoisophthalic acid 23341-13-1 Price
ACM168618426 2-Methylthiophenylboronic acid 2-Methylthiophenylboronic acid 168618-42-6 Price
ACM170981267 2-Fluoro-4-methylphenylboronic acid 2-Fluoro-4-methylphenylboronic acid 170981-26-7 Price
ACM175883600 3-Chloro-4-methoxyphenylboronic acid 3-Chloro-4-methoxyphenylboronic acid 175883-60-0 Price
ACM175883633 3-Chloro-4-methylphenylboronic acid 3-Chloro-4-methylphenylboronic acid 175883-63-3 Price
ACM178305992 2-Fluoro-4-biphenylylboronic acid 2-Fluoro-4-biphenylylboronic acid 178305-99-2 Price
ACM182344258 4-Fluoronaphtalene-1-boronic acid 4-Fluoronaphtalene-1-boronic acid 182344-25-8 Price
ACM186497676 4-Propoxyphenylboronic acid 4-Propoxyphenylboronic acid 186497-67-6 Price
ACM190661291 2-Benzyloxyphenylboronic acid 2-Benzyloxyphenylboronic acid 190661-29-1 Price
ACM192182562 4-Isoquinolineboronic acid 4-Isoquinolineboronic acid 192182-56-2 Price
ACM204841190 3-Acetylphenylboronic acid 3-Acetylphenylboronic acid 204841-19-0 Price
ACM206551431 5-Acetyl-2-thienylboronic acid 5-Acetyl-2-thienylboronic acid 206551-43-1 Price
ACM216485868 3-Isopropoxyphebylboronic acid 3-Isopropoxyphebylboronic acid 216485-86-8 Price
ACM219735996 2-Chloro-4-methoxyphenylboronic acid 2-Chloro-4-methoxyphenylboronic acid 219735-99-6 Price
ACM221037985 3-Iodophenylboronic acid 3-Iodophenylboronic acid 221037-98-5 Price
ACM22237134 4-Ethoxyphenylboronic acid 4-Ethoxyphenylboronic acid 22237-13-4 Price
ACM24067172 4-Nitrophenylboronic acid 4-Nitrophenylboronic acid 24067-17-2 Price
ACM24464639 N-Decylboronic acid N-Decylboronic acid 24464-63-9 Price
ACM248270259 3-Fluoro-4-formylphenylboronic acid 3-Fluoro-4-formylphenylboronic acid 248270-25-9 Price
ACM2493847 4-N-Octyloxybenzoic acid 4-N-Octyloxybenzoic acid 2493-84-7 Price
ACM254993594 2-Chloro-4-trifluoromethylphenylboronic acid 2-Chloro-4-trifluoromethylphenylboronic acid 254993-59-4 Price
ACM259209206 5-Fluoro-2-hydroxybenzeneboronic acid 5-Fluoro-2-hydroxybenzeneboronic acid 259209-20-6 Price
ACM26311455 4-Pentylbenzoic acid 4-Pentylbenzoic acid 26311-45-5 Price
ACM268218946 4-Benzoylbenzeneboronic acid 4-Benzoylbenzeneboronic acid 268218-94-6 Price
ACM28447203 3-Vinylbenzoic acid 3-Vinylbenzoic acid 28447-20-3 Price
ACM313545721 2-Chloro-4-fluorophenylboronic acid 2-Chloro-4-fluorophenylboronic acid 313545-72-1 Price
ACM328956612 3-Chloro-5-fluorophenylboronic acid 3-Chloro-5-fluorophenylboronic acid 328956-61-2 Price
ACM3321640 1-Butanephosphonic acid 1-Butanephosphonic acid 3321-64-0 Price
ACM34420172 Phenethylboronic acid Phenethylboronic acid 34420-17-2 Price
ACM351422736 3-Aminocarbonylphenylboronic acid 3-Aminocarbonylphenylboronic acid 351422-73-6 Price
ACM352525985 6-Ethoxy-2-naphthaleneboronic acid 6-Ethoxy-2-naphthaleneboronic acid 352525-98-5 Price
ACM352534793 2-Fluoro-5-formylphenylboronic acid 2-Fluoro-5-formylphenylboronic acid 352534-79-3 Price
ACM352534817 3-Butoxyphenylboronic acid 3-Butoxyphenylboronic acid 352534-81-7 Price
ACM352535832 5-Chloro-2-fluorophenylboronic acid 5-Chloro-2-fluorophenylboronic acid 352535-83-2 Price
ACM3575313 4-N-Octylbenzoic acid 4-N-Octylbenzoic acid 3575-31-3 Price
ACM374538019 4-Fluoro-3-formylphenylboronic acid 4-Fluoro-3-formylphenylboronic acid 374538-01-9 Price
ACM374538031 2-Methoxycarbonylphenylboronic acid 2-Methoxycarbonylphenylboronic acid 374538-03-1 Price
ACM376581247 Quinoline-6-boronic acid Quinoline-6-boronic acid 376581-24-7 Price
ACM380430546 2-Aminocarbonylphenylboronic acid 2-Aminocarbonylphenylboronic acid 380430-54-6 Price
ACM38350877 4-N-Heptylbenzoic acid 4-N-Heptylbenzoic acid 38350-87-7 Price
ACM401815983 2-Fluoropyridine-4-boronic acid 2-Fluoropyridine-4-boronic acid 401815-98-3 Price
ACM406482197 2-Fluoro-5-methoxyphenylboronic acid 2-Fluoro-5-methoxyphenylboronic acid 406482-19-7 Price
ACM4334876 3-Ethoxycarbonylphenylboronic acid 3-Ethoxycarbonylphenylboronic acid 4334-87-6 Price
ACM444120916 2-Chloropyridine-5-boronic acid 2-Chloropyridine-5-boronic acid 444120-91-6 Price
ACM168267990 3-Fluoro-4-methylphenylboronic acid 3-Fluoro-4-methylphenylboronic acid 168267-99-0 Price
ACM1692155 Pyridine-4-boronic acid Pyridine-4-boronic acid 1692-15-5 Price
ACM1765931 4-Fluorobenzeneboronic acid 4-Fluorobenzeneboronic acid 1765-93-1 Price
ACM179113907 3-(Trifluoromethoxy)phenylboronic acid 3-(Trifluoromethoxy)phenylboronic acid 179113-90-7 Price
ACM17933038 3-Methylphenylboronic acid 3-Methylphenylboronic acid 17933-03-8 Price
ACM179897940 5-Fluoro-2-methoxyphenylboronic acid 5-Fluoro-2-methoxyphenylboronic acid 179897-94-0 Price
ACM179899071 2-Methoxy-4-fluorophenylboronic acid 2-Methoxy-4-fluorophenylboronic acid 179899-07-1 Price
ACM192182540 3,5-Dimethoxyphenylboronic acid 3,5-Dimethoxyphenylboronic acid 192182-54-0 Price
ACM27329700 2-Formylfuran-5-boronic acid 2-Formylfuran-5-boronic acid 27329-70-0 Price
ACM32316920 2-Naphthaleneboronic acid 2-Naphthaleneboronic acid 32316-92-0 Price
ACM352303674 2-Fluoro-3-methoxyphenylboronic acid 2-Fluoro-3-methoxyphenylboronic acid 352303-67-4 Price
ACM355386946 Quinoline-5-boronic acid Quinoline-5-boronic acid 355386-94-6 Price
ACM381248040 2-Chloropyridine-3-boronic acid 2-Chloropyridine-3-boronic acid 381248-04-0 Price
ACM3900898 2-Chlorophenylboronic acid 2-Chlorophenylboronic acid 3900-89-8 Price
ACM4334887 4-Ethoxycarbonylphenylboronic acid 4-Ethoxycarbonylphenylboronic acid 4334-88-7 Price
ACM5683318 3-Trimethylsilylpropynoic acid 3-Trimethylsilylpropynoic acid 5683-31-8 Price
ACM641144163 10-Bromoanthracene-9-boronic acid 10-Bromoanthracene-9-boronic acid 641144-16-3 Price
ACM452972086 2-Bromo-3-pyridineboronic acid 2-Bromo-3-pyridineboronic acid 452972-08-6 Price
ACM4721179 N-Hexadecylphosphonic acid N-Hexadecylphosphonic acid 4721-17-9 Price
ACM505083045 3-Fluoro-4-methoxycarbonylphenylboronic acid 3-Fluoro-4-methoxycarbonylphenylboronic acid 505083-04-5 Price
ACM5122952 Biphenyl-3-boronic acid Biphenyl-3-boronic acid 5122-95-2 Price
ACM51323434 3-Bromomethylphenylboronic acid 3-Bromomethylphenylboronic acid 51323-43-4 Price
ACM5137702 N-Dodecylphosphonic acid N-Dodecylphosphonic acid 5137-70-2 Price
ACM5438197 4-Propoxybenzoic acid 4-Propoxybenzoic acid 5438-19-7 Price
ACM5519233 4-N-Decyloxybenzoic acid 4-N-Decyloxybenzoic acid 5519-23-3 Price
ACM55499439 3,4-Dimethylphenylboronic acid 3,4-Dimethylphenylboronic acid 55499-43-9 Price
ACM57079013 11-Maleimidoundecanoic acid 11-Maleimidoundecanoic acid 57079-01-3 Price
ACM63139219 4-Ethylphenylboronic acid 4-Ethylphenylboronic acid 63139-21-9 Price
ACM68572872 9-Phenanthracenylboronic acid 9-Phenanthracenylboronic acid 68572-87-2 Price
ACM6874608 1-Decylphosphonic acid 1-Decylphosphonic acid 6874-60-8 Price
ACM762287570 4-Chloro-2-methoxyphenylboronic acid 4-Chloro-2-methoxyphenylboronic acid 762287-57-0 Price
ACM763120587 1H-pyrazole-4-boronic acid 1H-pyrazole-4-boronic acid 763120-58-7 Price
ACM80041890 Isopropylboronic acid Isopropylboronic acid 80041-89-0 Price
ACM84110407 Isobutaneboronic acid Isobutaneboronic acid 84110-40-7 Price
ACM843663183 4-Cyano-3-fluorophenylboronic acid 4-Cyano-3-fluorophenylboronic acid 843663-18-3 Price
ACM845551442 4-(Benzyloxy)-3-chlorophenylboronic acid 4-(Benzyloxy)-3-chlorophenylboronic acid 845551-44-2 Price
ACM850036281 Cyclopenten-1-ylboronic acid Cyclopenten-1-ylboronic acid 850036-28-1 Price
ACM851335096 4-Carboxy-2-chlorophenylboronic acid 4-Carboxy-2-chlorophenylboronic acid 851335-09-6 Price
ACM854778317 4-Fluoro-3-methoxybenzeneboronic acid 4-Fluoro-3-methoxybenzeneboronic acid 854778-31-7 Price
ACM871332955 4-Chloro-3-cyanophenylboronic acid 4-Chloro-3-cyanophenylboronic acid 871332-95-5 Price
ACM872041855 5-Chloropyridine-3-boronic acid 5-Chloropyridine-3-boronic acid 872041-85-5 Price
ACM872041866 5-Fluoropyridin-3-ylboronic acid 5-Fluoropyridin-3-ylboronic acid 872041-86-6 Price
ACM872460123 3-Carboxy-4-fluorophenylboronic acid 3-Carboxy-4-fluorophenylboronic acid 872460-12-3 Price
ACM88496882 Buntane-2-boronic acid Buntane-2-boronic acid 88496-88-2 Price
ACM89490051 1-Cyclohexenylboronic acid 1-Cyclohexenylboronic acid 89490-05-1 Price
ACM89598969 3-Bromophenylboronic acid 3-Bromophenylboronic acid 89598-96-9 Price
ACM89787122 2-Isopropylphenylboronic acid 2-Isopropylphenylboronic acid 89787-12-2 Price
ACM91129690 2-Butoxyphenylboronic acid 2-Butoxyphenylboronic acid 91129-69-0 Price
ACM91983141 2-Bromomethylphenylboronic acid 2-Bromomethylphenylboronic acid 91983-14-1 Price
ACM94839073 3,4-Methylenedioxyphenylboronic acid 3,4-Methylenedioxyphenylboronic acid 94839-07-3 Price
ACM957060887 3-Chloro-2-methoxypyridine-4-boronic acid 3-Chloro-2-methoxypyridine-4-boronic acid 957060-88-7 Price
ACM98437231 Benzo[b]thien-2-ylboronic acid Benzo[b]thien-2-ylboronic acid 98437-23-1 Price
ACM98437242 Benzofuran-2-boronic acid Benzofuran-2-boronic acid 98437-24-2 Price
ACM99769194 3-Methoxycarbonylphenylboronic acid 3-Methoxycarbonylphenylboronic acid 99769-19-4 Price
ACM5411701 Tetrabromoterephthalic acid Tetrabromoterephthalic acid 5411-70-1 Price
ACM608377 Dibromomaleic acid Dibromomaleic acid 608-37-7 Price
ACM468718301 5-Cyano-2-fluorophenylboronic acid 5-Cyano-2-fluorophenylboronic acid 468718-30-1 Price
ACM63503606 3-Chlorophenylboronic acid 3-Chlorophenylboronic acid 63503-60-6 Price
ACM78495633 2-Fluoro-6-methoxyphenylboronic acid 2-Fluoro-6-methoxyphenylboronic acid 78495-63-3 Price
ACM78887395 3-Acetamidophenylboronic acid 3-Acetamidophenylboronic acid 78887-39-5 Price
ACM89694484 5-Chloro-2-methoxyphenylboronic acid 5-Chloro-2-methoxyphenylboronic acid 89694-48-4 Price
ACM90002361 2-Ethylphenylboronic acid 2-Ethylphenylboronic acid 90002-36-1 Price
ACM90555661 3-Ethoxyphenylboronic acid 3-Ethoxyphenylboronic acid 90555-66-1 Price

Share

Interested in our Services & Products ? Need detailed information?
facebook twitter linkedin

Contact us

Email:
Tel:1-201-478-8534
1-516-662-5404
Fax: 1-516-927-0118
Address: 2200 Smithtown Avenue, Room 1 Ronkonkoma, NY 11779-7329 USA