XYD049

• CAS: 3006788-11-7
• Catalog Number: ACM-MG-3006788117
• Category: Molecular Glues
• Molecular Weight: 811.66
• Molecular Formula: C35H35BrN6O10S
• Description: XYD049 (compound 7d) is a CRBN-type molecular glue targeting GSPT1 (DC50=19 nM), which can be used for the research of MYC-driven castration-resistant prostate cancer (CRPC). XYD049 can effectively inhibit the growth of 22Rv1 cells (IC50=7 nM) and has in vivo antitumor efficacy.
• IUPAC Name: 2-[[5-[(5-bromo-2-methoxyphenyl)sulfonylamino]-3-methyl-1,2-benzoxazol-6-yl]oxy]-N-[5-[[2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindol-4-yl]amino]pentyl]acetamide
• SMILES: CC1=NOC2=CC(OCC(NCCCCCNC3=CC=CC(C(N4C5CCC(NC5=O)=O)=O)=C3C4=O)=O)=C(C=C21)NS(C6=C(C=CC(Br)=C6)OC)(=O)=O
• InChI: InChI=1S/C35H35BrN6O10S/c1-19-22-16-24(41-53(48,49)29-15-20(36)9-11-26(29)50-2)28(17-27(22)52-40-19)51-18-31(44)38-14-5-3-4-13-37-23-8-6-7-21-32(23)35(47)42(34(21)46)25-10-12-30(43)39-33(25)45/h6-9,11,15-17,25,37,41H,3-5,10,12-14,18H2,1-2H3,(H,38,44)(H,39,43,45)
• InChI Key: YKMPUYQTESMTQD-UHFFFAOYSA-N
• Shipping: Generally, shipped at room temperature in continental US; may vary elsewhere.
• Storage Conditions: Please store the product under the recommended conditions.