WIZ degrader 8

• CAS: 2879251-26-8
• Catalog Number: ACM-MG-2879251268
• Category: Molecular Glues
• Molecular Weight: 385.46
• Molecular Formula: C21H27N3O4
• Description: WIZ degrader 8 (compound 10) is a potent and selective degrader of the transcription factor WIZ, which can potently induce HbF expression. WIZ degrader 8 can lead to WIZ degradation and induce HbF expression, and has the potential to be an inhibitor of sickle cell disease.
• IUPAC Name: 3-[6-[(3R,5R)-1-ethyl-5-methylpiperidin-3-yl]oxy-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione
• SMILES: O=C1N(C2C(NC(CC2)=O)=O)CC3=CC(O[C@H]4CN(C[C@@H](C4)C)CC)=CC=C31
• InChI: InChI=1S/C21H27N3O4/c1-3-23-10-13(2)8-16(12-23)28-15-4-5-17-14(9-15)11-24(21(17)27)18-6-7-19(25)22-20(18)26/h4-5,9,13,16,18H,3,6-8,10-12H2,1-2H3,(H,22,25,26)/t13-,16-,18?/m1/s1
• InChI Key: DADIMSMRMNXYMS-HZBOCPGUSA-N
• Shipping: Generally, shipped at room temperature in continental US; may vary elsewhere.
• Storage Conditions: Please store the product under the recommended conditions.