CAS
1398053-45-6 Purity
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1398053-45-6 Purity
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VNPP433-3β
CAS
1630820-51-7
Catalog Number
ACM-MG-1630820517
Category
Molecular Glues
Molecular Weight
438.61
Molecular Formula
C29H34N4
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Specification
Description
VNPP433-3β (Galeterone 3β-imidazole) is an orally active molecular glue degrader, which degrades androgen receptor (AR) and its splice variants (AR-Vs) and MAP kinase-interacting serine/threonine protein kinase Mnk1/2.
Synonyms
Galeterone 3β-imidazole
IUPAC Name
1-[(3S,8R,9S,10R,13S,14S)-3-imidazol-1-yl-10,13-dimethyl-2,3,4,7,8,9,11,12,14,15-decahydro-1H-cyclopenta[a]phenanthren-17-yl]benzimidazole
SMILES
C[C@@]12[C@](CC=C2N3C4=CC=CC=C4N=C3)([H])[C@@]5([H])[C@]([C@@]6(C(C[C@@H](N7C=CN=C7)CC6)=CC5)C)([H])CC1
InChI
InChI=1S/C29H34N4/c1-28-13-11-21(32-16-15-30-18-32)17-20(28)7-8-22-23-9-10-27(29(23,2)14-12-24(22)28)33-19-31-25-5-3-4-6-26(25)33/h3-7,10,15-16,18-19,21-24H,8-9,11-14,17H2,1-2H3/t21-,22-,23-,24-,28-,29-/m0/s1
InChI Key
LKIKZGJOIUJYGD-IRGTZXILSA-N
Appearance
Light yellow to yellow solid
Shipping
Generally, shipped at room temperature in continental US; may vary elsewhere.
Storage Conditions
4 °C, protect from light, stored under nitrogen
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