CAS
1860875-51-9 Purity
>99.5%
1860875-51-9 Purity
>99.5%
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Tz-Thalidomide
CAS
2087490-42-2
Catalog Number
ACM-MG-2087490422
Category
Molecular Glues
Molecular Weight
571.58
Molecular Formula
C29H29N7O6
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Specification
Description
Tz-Thalidomide is a tetrazine tagged Thalidomide (Ligands for E3 Ligase). Tz-Thalidomide has binding affinity for BRD4, with IC50s of 46.25 μM (BRD4-1) and 62.55 μM (BRD4-2).
Synonyms
6-((2-(2,6-Dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)oxy)-N-(4-(6-methyl-1,2,4,5-tetrazin-3-yl)benzyl)hexanamide
IUPAC Name
6-[2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindol-4-yl]oxy-N-[[4-(6-methyl-1,2,4,5-tetrazin-3-yl)phenyl]methyl]hexanamide
SMILES
O=C(CCCCCOC1=C(C(N(C2CCC(NC2=O)=O)C3=O)=O)C3=CC=C1)NCC(C=C4)=CC=C4C5=NN=C(C)N=N5
InChI
InChI=1S/C29H29N7O6/c1-17-32-34-26(35-33-17)19-11-9-18(10-12-19)16-30-23(37)8-3-2-4-15-42-22-7-5-6-20-25(22)29(41)36(28(20)40)21-13-14-24(38)31-27(21)39/h5-7,9-12,21H,2-4,8,13-16H2,1H3,(H,30,37)(H,31,38,39)
InChI Key
AHPHLKGKBKDTDE-UHFFFAOYSA-N
Appearance
Pink to red solid
Shipping
Generally, shipped at room temperature in continental US; may vary elsewhere.
Storage Conditions
Store at 4 °C
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