trans-13-Octadecenoic acid

• CAS: 693-71-0
• Catalog Number: ACM693710
• Category: Main Products
• Molecular Weight: 282.46
• Molecular Formula: C₁₈H₃₄O₂
• Synonyms: TRANS-13-OCTADECENOIC ACID;trans-13-octadecenoic acid (C18:1,*(trans-13))
• IUPAC Name: (E)-octadec-13-enoicacid
• SMILES: CCCCC=CCCCCCCCCCCCC(=O)O
• InChI Key: BDLLSHRIFPDGQB-AATRIKPKSA-N
• Exact Mass: 282.25600
• Hazard Statements: Xi
• Safety Description: 26-36

Case Study

Analysis of trans-13-Octadecenoic Acid as a Primary Anti-inflammatory Component in Yucca elephantipes Roots

Khan, Muhammad Shoaib, et al. Pakistan Journal of Pharmaceutical Sciences 35.6 (2022).

Plant-derived fatty acids and phenolics remain attractive for anti-inflammatory product development because of their widespread availability and generally favorable safety profiles. The work aimed to profile the chemical constituents of Yucca elephantipes roots by GC-MS, evaluate the extract's anti-inflammatory potential in standard in-vitro and in-vivo models, and identify key constituents-particularly trans-13-octadecenoic acid-that may underlie the observed bioactivity.
Key Findings
· GC-MS analysis detected fifteen compounds in the methanolic root extract; trans-13-octadecenoic acid was the major constituent (reported 84.21% of the detected profile), with n-hexadecanoic acid at 5.21% and 4-hydroxybenzoic acid at 2.17%.
· Oxidative Burst Assay: The root extract demonstrated a potent inhibitory effect of 74.58 ± 0.32%, with an IC50 value of 15.3 ± 2.2 μg/mL. This activity was comparable to the standard drug Ibuprofen, which showed 73.20 ± 0.17% inhibition and an IC50 of 11.2 ± 0.98 μg/mL. This result indicates a strong ability to suppress inflammation at the cellular level.
· In the carrageenan paw edema model the extract produced significant anti-edematous effects at both 100 and 200 mg/kg oral doses, with the 200 mg/kg dose yielding a reported 88.89 ± 0.015% anti-inflammatory effect. Acute toxicity screening reported that doses below 8 g/kg were tolerated in albino rats.