CAS
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STING Degrader-1
Catalog Number
ACM-MG-00047
Category
Molecular Glues
Molecular Weight
504.49
Molecular Formula
C26H24N4O7
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Specification
Description
STING Degrader-1 (compound 2), a molecular glue, is a potent STING degrader that covalently binds to STING and E3 ligase. STING Degrader-1 exhibits a "hook effect", that degrades 75% STING protein at 10 μM, and degrades ca. 30% STING protein at 30 μM.
SMILES
O=C(NC1=CC=C(N2CCN(C(/C=C/C(C3=CC=C(OC)C=C3)=O)=O)CC2)C=C1)C4=CC=C([N+]([O-])=O)O4
Shipping
Generally, shipped at room temperature in continental US; may vary elsewhere.
Storage Conditions
Please store the product under the recommended conditions.
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