SKL2001 free base

• CAS: 909089-13-0
• Catalog Number: ACM909089130
• Category: Agonists
• Molecular Weight: 286.29
• Molecular Formula: C14H14N4O3
• Description: SKL-2001 is a novel agonist of Wnt/β-catenin signaling pathway. SKL2001 suppresses colon cancer spheroid growth through regulation of the E-cadherin/β-Catenin complex. SKL2001 inhibited proliferation of colon cancer cells cultured in 3D spheroid and induced them accumulation in the G0/G1 phase of the cell cycle with a reduced c-myc level.
• Synonyms: SKL-2001; SKL 2001; SKL2001; Wnt Agonist II
• IUPAC Name: 5-(Furan-2-yl)-N-(3-imidazol-1-ylpropyl)-1,2-oxazole-3-carboxamide
• Canonical SMILES: O=C(C1=NOC(C2=CC=CO2)=C1)NCCCN3C=CN=C3
• InChI: InChI=1S/C14H14N4O3/c19-14(16-4-2-6-18-7-5-15-10-18)11-9-13(21-17-11)12-3-1-8-20-12/h1,3,5,7-10H,2,4,6H2,(H,16,19)
• InChI Key: PQXINDBPUDNMPE-UHFFFAOYSA-N
• Solubility: Soluble in DMSO
• Appearance: Solid powder
• Shelf Life: >2 years if stored properly
• Storage: Dry, dark and at 0-4 °C for short term (days to weeks) or -20 °C for long term (months to years).
• Drug Formulation: This drug may be formulated in DMSO
• Elemental Analysis: C, 58.74; H, 4.93; N, 19.57; O, 16.77
• Exact Mass: 286.1066
• HS Tariff Code: 2934.99.9001
• Shipping: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
• Stock Solution Storage: 0-4 °C for short term (days to weeks), or -20 °C for long term (months).