SB-265610

• CAS: 211096-49-0
• Catalog Number: ACM211096490
• Category: Antagonists
• Molecular Weight: 357.17
• Molecular Formula: C14H9BrN6O
• Description: SB-265610 is a potent CXCR2 antagonist that inhibits CINC-1-mediated but not C5a-mediated Ca2+ mobilization (IC50 values are 3.4 and 6800 nM respectively). It inhibits CINC-induced chemotaxis and attenuates neutrophil accumulation in inflammatory lung injury in vivo.
• Synonyms: SB-265610; SB 265610; SB265610
• IUPAC Name: N-(2-Bromophenyl)-N'-(7-cyano-1H-benzotriazol-4-yl)urea
• Canonical SMILES: O=C(NC1=C2N=NNC2=C(C#N)C=C1)NC3=CC=CC=C3Br
• InChI: InChI=1S/C14H9BrN6O/c15-9-3-1-2-4-10(9)17-14(22)18-11-6-5-8(7-16)12-13(11)20-21-19-12/h1-6H,(H2,17,18,22)(H,19,20,21)
• InChI Key: SEDUMQWZEOMXSO-UHFFFAOYSA-N
• Solubility: Soluble in DMSO
• Appearance: Solid powder
• Shelf Life: >2 years if stored properly
• Storage: Dry, dark and at 0-4 °C for short term (days to weeks) or -20 °C for long term (months to years).
• Drug Formulation: This drug may be formulated in DMSO
• Elemental Analysis: C, 47.08; H, 2.54; Br, 22.37; N, 23.53; O, 4.48
• Exact Mass: 356.0021
• HS Tariff Code: 2934.99.03.00
• Shipping: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
• Stock Solution Storage: 0-4 °C for short term (days to weeks), or -20 °C for long term (months).