CAS
296797-88-1 Purity
≥95%
296797-88-1 Purity
≥95%
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PVTX-405
CAS
2991021-08-8
Catalog Number
ACM-MG-2991021088
Category
Molecular Glues
Molecular Weight
525.60
Molecular Formula
C30H31N5O4
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- Product Description
- Case Study
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- Synthetic Use
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Specification
Description
PVTX-405 is a selective and oral active IKZF2 molecular glue degrader with a DC50 of 0.7 nM and a Dmax of 91%. PVTX-405 enhances degradation efficiency, significantly reduces off-target degradation, and alleviates hERG inhibition with IC50 of 48 µM.
SMILES
O=C1C2=CC=C(C(OC3)=C2CN1[C@@H]4C(NC(CC4)=O)=O)C3(CC5)CCN5CC6=CC(C7=CN(N=C7)C)=CC=C6
Shipping
Generally, shipped at room temperature in continental US; may vary elsewhere.
Storage Conditions
Please store the product under the recommended conditions.
Please kindly note that our products are for research use only.
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