Structure

Polyvinylpyrrolidone

CAS
9003-39-8
Catalog Number
ACM9003398-15
Category
Polymer/Macromolecule
Molecular Weight
avg.40000
Molecular Formula
(C6H9NO)n

If you have any other questions or need other size, please get a quote.

  • Product Description
  • Case Study
  • Custom Reviews
  • Custom Q&A
  • Synthetic Use
  • Related Resources

Specification

Description
PVP has biocompatibility, low toxicity, adhesive characteristics, complexing stability, relatively inert behavior, and is resistant to thermal degradation. It is readily prepared by the polymerization of N-vinyl-2-pyrrolidone or by Reppe synthesis technique.
Synonyms
PVP; Povidone; Polyvidone
IUPAC Name
1-ethenylpyrrolidin-2-one
Canonical SMILES
C=CN1CCCC1=O
InChI
InChI=1S/C6H9NO/c1-2-7-5-3-4-6(7)8/h2H,1,3-5H2
InChI Key
WHNWPMSKXPGLAX-UHFFFAOYSA-N
Boiling Point
90-93 °C;96 °C @ 14 mm Hg; 193 °C @ 400 mm Hg;at 1.3kPa: 90-93 °C;194°F
Melting Point
13.9 °C;13 °C;57°F
Flash Point
100.5 °C (213 °F) open cup;95 °C closed cup;93 °C;199.4°F
Density
1.23 to 1.29 (NTP, 1992);1.23-1.29;1.04 @ 24 °C/4 °C;Relative density (water = 1): 1.04;1..04
Solubility
greater than or equal to 100 mg/mL at 68° F (NTP, 1992);Soluble in water and in ethanol. Insoluble in ether;Sol in water giving a colloidal soln; practically insol in ether; sol in alcohol, chloroform;Sol in chlorinated hydrocarbons, amines, nitro paraffins, lower wt fatty acids;Soluble in water;Soluble in alcohol; practically insoluble in chloroform, carbon tetrachloride, ether, solvent hexane, acetone.;Practically insoluble in acetone, and light petroleum.;Soluble in water and many organic solvents;In water, 5.2X10+4 mg/L @ 25 °C /Estimated/;Solubility in water: good;Solubility in water: very good
Appearance
Powder
Application
Polyvinylpyrrolidone (PVP),also known as K90 is a water soluble polymer with good bio-stability. It is chemically stable, has low toxicity and is biocompatible. Hence, it is useful in a variety of s such as cosmetics, tissue engineering, and biomedical engineering.
Autoignition Temperature
240 °C;364 °C
Color/Form
Faintly yellow solid;WHITE TO CREAMY WHITE POWDER;White, free-flowing, amorphous powder or aqueous solution;Yellowish-brown amorphous hygroscopic powder;Clear to light straw colored liquid
Complexity
120
Covalently-Bonded Unit Count
1
Decomposition
When heated to decomposition it emits toxic fumes of nitroxides. /Poly(1-vinyl-2-pyrrolidinone) homopolymer and Hueper's polymer 1-7/;When heated to decomposition it emits toxic fumes of /nitrogen oxide/.
EC Number
201-800-4
Exact Mass
111.068413911
Features And Benefits
This product has good hydrophobicity to meet your specific application needs
Form
powder or crystals (or flakes)
Formal Charge
0
H-Bond Acceptor
1
H-Bond Donor
0
Heavy Atom Count
8
Hydrogen Bond Acceptor Count
1
Hydrogen Bond Donor Count
0
ICSC Number
1471;1478
Isomeric SMILES
C=CN1CCCC1=O
LogP
0.37 (LogP);log Kow = 0.37;0.4
MDL Number
MFCD00149016
Monoisotopic Mass
111.068413911
NACRES
NA.23
NSC Number
683040;142693;114022;10222
Odor
ODORLESS;A slight characteristic odor
Other Experimental
A 3.5% soln develops an osmotic pressure of 400 mm water;Forms complexes with a great many substances (eg iodine, polyacids, toxins, drugs, chemicals & dyes);Highly hygroscopic and should be stored under air tight conditions.;Solutions do not give the familiar starch test when freshly prepared.;Freezing pt: 13.5 °C;Henry's Law constant = 5.5X10-8 atm-cu m/mol @ 25 °C /Estimated/;Hydroxyl radical reaction rate constant = 3.7X10-11 cu cm/molecule-sec @ 25 °C /Estimated/
Packaging
250 g in poly bottle
1 kg in poly bottle
PubChem ID
24887621
Quality Level
200
Refractive Index
Index of refraction = 1.511 @ 25 °C/D
Rotatable Bond Count
1
RTECS Number
UY6107000
Safety Description
22-24/25
Stability
Stable under recommended storage conditions.;Polymerizes readily in the presence of oxygen.;The product is stabilized against spontaneous polymerization prior to dispatch. It can however polymerize if the shelf-life or storage temperature are greatly exceeded.
Storage Temperature
2-8°C
Topological Polar Surface Area
20.3 Ų
UNII
76H9G81541
Vapor Density
Relative vapor density (air = 1): 3.83;3.83
Vapor Pressure
1.1X10-11 mm Hg @ 25 °C /Estimated/;Vapor pressure, Pa at 20 °C: 12;0.09 mmHg
Viscosity
2.07 cps @ 25 °C;2.07 cP at 25 °C
XLogP3
0.4

Multifunctional Role of Polyvinylpyrrolidone in Pharmaceutical Preparations

Luo Y, et al. AAPS PharmSciTech, 2021, 22. 1-16.

In the pharmaceutical field, polyvinylpyrrolidone (PVP) can be used as an adhesive, coating agent, suspending agent, pore-forming agent, solubilizer and stabilizer, etc., thanks to its inert, non-toxic and biocompatible properties. characteristic. PVP of different molecular weights and concentrations can be used in a variety of formulations for different uses. The multifunctional role of PVP in pharmaceutical formulations can mostly be explained by its viscosity, solubility, hydrophilicity and hydrogen bond-forming abilities.
The main applications of PVP in the medical field
· Improve the bioavailability of drugs: keeping amorphous state; increasing surface area; increasing drug wettability.
· Improve the stability of drugs: increasing the viscosity; generating steric barriers; interactions between molecules.
· Improve the physical and mechanical properties: rigid/hygroscopic/hydrophilic properties; surface modification; high plastic deformation.
· Regulate the rate of drug release: pores formation after dissolution; formation of viscous layer.
· Prolong the in vivo circulation time of liposomes.

Application of Polyvinylpyrrolidone in Nanoparticle Synthesis

Kallum M. Koczkur, et al. Dalton Trans., 2015, 44, 17883-17905.

In colloidal nanoparticle synthesis, polyvinylpyrrolidone (PVP) can be used as a surface stabilizer, growth regulator, nanoparticle dispersant, and reducing agent.
Examples of PVP in colloidal nanoparticle synthesis
· PVP in the synthesis of metallic NPs: PVP is widely used as a stabilizing and shape-directing agent in the polyol synthesis of metallic NPs. Examples of these NPs include plasmonic elements (Ag, Au, Cu), catalytic elements (Pd, Pt), magnetic elements (Co, Ni) and bimetallic compositions (Au-M, PtM).
· PVP in the synthesis of metal oxide NPs: These oxides include compounds as iron oxides, more complex ferrites, as well as other transition metal and main group metal oxides, but also rare-earth metal oxides.
· Metal chalcogenide nanostructures with PVP: PVP serves as an excellent stabilizer and shape-directing agent also during metal chalcogenide (MC) NPs synthesis preventing their aggregation and passivating surface states. Furthermore, the use of PVP can enhance the optical properties of MC NPs under certain conditions.

What is the molecular formula of Polyvinylpyrrolidone?

The molecular formula of Polyvinylpyrrolidone is C6H9NO.

What is the molecular weight of Polyvinylpyrrolidone?

The molecular weight of Polyvinylpyrrolidone is 111.14 g/mol.

What is another name for Polyvinylpyrrolidone?

Another name for Polyvinylpyrrolidone is N-Vinyl-2-pyrrolidone.

What is the IUPAC name of Polyvinylpyrrolidone?

The IUPAC name of Polyvinylpyrrolidone is 1-ethenylpyrrolidin-2-one.

What is the InChIKey of Polyvinylpyrrolidone?

The InChIKey of Polyvinylpyrrolidone is WHNWPMSKXPGLAX-UHFFFAOYSA-N.

What is the CAS number of Polyvinylpyrrolidone?

The CAS number of Polyvinylpyrrolidone is 9003-39-8.

What is the chemical safety summary of Polyvinylpyrrolidone?

The chemical safety summary of Polyvinylpyrrolidone states that it is a white powder that is compatible with a wide range of hydrophilic and hydrophobic resins.

What is the role of Polyvinylpyrrolidone in pharmaceutical tablets?

Polyvinylpyrrolidone, also known as Povidone or PVP, is used as a binder in many pharmaceutical tablets.

What are the technical applications of Polyvinylpyrrolidone?

Polyvinylpyrrolidone is used in many technical applications as an adhesive, additive, and emulsifier.

What is the controversy surrounding the clinical effectiveness of Polyvinylpyrrolidone on wound healing?

It has been demonstrated in a few clinical studies that the application of Polyvinylpyrrolidone in wounds was associated with impaired wound healing, reduced wound strength, or infection in open wounds.

Alfa Chemistry

For product inquiries, please use our online system or send an email to .

Alfa Chemistry
Inquiry Basket
qrcode
Download
Verification code
* I hereby give my consent that I may receive marketing e-mails with information on existing and new services from this company. I know that I can opt-out from receiving such e-mails at any time or by using the link which will be provided in each marketing e-mail.