Polyethylene glycol,mw 6800(8,000cs(99°c))

• CAS: 25322-68-3
• Catalog Number: ACM25322683-1
• Category: Polymer/Macromolecule
• Molecular Weight: 6800
• Boiling Point: >200°C (dec)
• Melting Point: 62°C
• Flash Point: 445°F
• Density: 1.111 (65°C)
• Alpha Sort: Polyethylene glycol
• Viscosity: 8,000cs (99°C)

Case Study

Multifunctional Applications of Polyethylene Glycol (PEG) in Drug Delivery

D'souza A A, et al. Expert opinion on drug delivery, 2016, 13(9): 1257-1275.

Polyethylene glycol (PEG) is the polymer of choice in drug delivery systems.The important application of PEG in drug delivery is clearly depicted in the Figure. Examples of PEG applications in drug delivery include solubilizers, permeation enhancer, long systemic circulating effect, anti-fouling of medical devices, drug targeting, release modifiers, tissue engineering, binders and plasticizers, de-aggregation and stabilization, and more.

Polyethylene Glycol Is Used to Improve the Dispersion of Cellulose Nanocrystals

Cheng, Dong, et al. Carbohydrate polymers, 2015, 123, 157-163.

Polyethylene glycol (PEG) can be used as a steric stabilizer in the preparation of dispersible nanoparticles. For example, PEG can improve the redispersibility of cellulose nanocrystals (CNC) in aqueous systems through adsorption. Based on PEG adsorbed CNC, the irreversible agglomeration of CNC after drying is basically eliminated.
Preparation of polyethylene glycol modified CNC
· The aqueous suspension containing CNC was transferred to a beaker so that a desired CNC concentration was reached. The required amount of PEG was then added and the aqueous system was stirred at 200 rpm using a magnetic stirrer at an ambient temperature for 3 h.
· After that, the CNC-PEG samples were subjected to centrifugation at 20,000 g force, followed by dialysis (molecular weight cut-off of 14,000) against deionized water for 3 days.
· The CNC-PEG samples were freeze-dried at -65°C and 0.37 mbar pressure for 2 days before being used in redispersion experiments.

Synthesis Method of Polyethylene Glycol-Assisted Lanthanum Oxide Nanoparticles

Kabir, Humayun, et al. Ceramics International, 2019, 45(1), 424-431.

High molecular weight polyethylene glycol (PEG) can be used to prepare lanthanum oxide nanoparticles (La2O3 NPs) via a facile sol-gel method. In this synthesis system, the concentration of PEG strongly affects the particle size and lattice strain of La2O3 NPs.
Sol-gel synthesis of La2O3 NPs with PEG
· Initially an 18.5 ml 20% aqueous solution of HNO3 was added dropwise to the 2 g micro-sized La2O3 powders with continuous and vigorous magnetic stirring. Continue this process until all the raw materials react to form an aqueous solution of lanthanum nitrate (La(NO3)3·6H2O).
· Different amounts of PEG were then added to produce a solution with different PEG concentrations. The resultant solution was stirred for a further 15 minutes using a magnetic stirrer.
· The solution was then kept in a water bath at 80 °C with continuous stirring for approximately 2 h until most of the water was evaporated and a clear gel was formed. The gel was allowed to cool down to room temperature.
· The transparent gel is dried and ground to obtain white powder, and the organic phase is removed by heat treatment and La(NO3)3 is decomposed.
· Finally, the resultant powder (La2O3 NPs) was calcined at a temperature of 750 °C using a programmable Muffle furnace in air atmosphere.

Custom Q&A

What is the molecular formula of polyethylene glycol?

The molecular formula of polyethylene glycol is (C2H4O)nH2O where n represents the number of ethylene oxide units corresponding to a molecular weight of about 6000.

How are PEGs produced?

PEGs are produced via the polymerization of ethylene oxide molecules to create joining units of ethylene glycol through an ether linkage.

What is the ratio of water molecules to PEG molecules in terms of hydrogen bonding?

PEGs can form hydrogen bonds with a ratio of 100 water molecules per one PEG molecule.

How do the physical and chemical properties of PEGs vary based on their molecular weight?

PEGs vary in their physical and chemical properties depending on their molecular weight. PEGs with molecular weights <1000 are liquids, while those with higher molecular weights turn into waxy solids.

What are some common preparations of PEGs?

Some common preparations of PEGs include PEG 3350 and PEG 400.

What are some applications of PEGs in various fields?

PEGs have various applications in medical and industrial areas.

What is the rationale for using PEG in gastroenterology?

PEGs are used in gastroenterology due to their water-binding capacity, lack of intestinal absorption, low toxicity, and limited enzymatic degradation or bacterial metabolism.

What is the European Community (EC) Number for polyethylene glycol?

The European Community (EC) Number for polyethylene glycol is 919-715-2.

What is the UNII (FDA Global Substance Registration System) for polyethylene glycol?

The UNII for polyethylene glycol is 3WJQ0SDW1A.

What is the boiling point of polyethylene glycol?

The boiling point of polyethylene glycol is greater than 200 degrees Celsius.