Piericidin a

• CAS: 2738-64-9
• Catalog Number: ACM2738649
• Category: Inhibitors
• Molecular Weight: 415.57
• Molecular Formula: C₂₅H₃₇NO₄
• Description: Piericidin A (AR-054) is a natural mitochondrial NADH-ubiquinone oxidoreductase (complex I) inhibitor. Piericidin A is a potent neurotoxin and inhibits mitochondrial respiration by disrupting the electron transport system through its action on NADH-ubiquinone reductase. Piericidin A is also a potential quorum-sensing inhibitor that suppresses the expression of the virulence genes of Erwinia carotovora subsp. atroseptica (Eca). Piericidin A is an ADC cytotoxin and has anti-bacterial, anticancer, insecticidal activity.
• Synonyms: PIERICIDIN A
• IUPAC Name: 2-[(2E,5E,7E,9R,10R,11E)-10-hydroxy-3,7,9,11-tetramethyltrideca-2,5,7,11-tetraenyl]-5,6-dimethoxy-3-methyl-1H-pyridin-4-one
• Canonical SMILES: COC1=C(C(C)=C(N=C1OC)C/C=C(C/C=C/C(C)=C/[C@@H](C)[C@H](/C(C)=C/C)O)\C)O
• InChI Key: BBLGCDSLCDDALX-LKGBESRRSA-N
• Boiling Point: 591.7ºC at 760 mmHg. 产品描述 安全性:
• Flash Point: 85ºC
• Density: 1.05 g/cm³
• Appearance: Liquid
• Storage: Solution, -20°C, 2 years
• Exact Mass: 415.27200
• Hazard Statements: T+
• H-Bond Acceptor: 5
• H-Bond Donor: 2
• Shipping: Can be shipped at room temperature, where not in use may vary.
• Source: Streptomyces sp. BCC24731