6-Phenyldodecane

• CAS: 2719-62-2
• Catalog Number: ACM2719622
• Category: Main Products
• Molecular Weight: 246.4308
• Molecular Formula: C₁₈H₃₀
• Synonyms: 6-phenyldodecane;BENZENE,(1-PENTYLHEPTYL)-;(1-Pentylheptyl)benzene;1-Pentylheptylbenzene;1-(dodecan-6-yl)benzene

Case Study

6-Phenyldodecane from Plantago ovata Seed Oil for Hepatoprotection Against Ketoprofen Toxicity

El-Feky, Amal M., et al. Bulletin of the national research Centre 42.1 (2018): 28.

6-Phenyldodecane, an alkylbenzene hydrocarbon, was identified as a major constituent (11.26%) in the unsaponifiable matter of Plantago ovata seed fixed oil. Together with other bioactive compounds (fatty acids, sterols, triterpenoids), it contributes to the oil's antioxidant and hepatorenal protective activity against ketoprofen-induced toxicity.
Isolation and Identification: P. ovata seeds were defatted with petroleum ether. The saponifiable and unsaponifiable fractions were analyzed by GC/MS. Column chromatography and preparative TLC isolated five steroidal compounds (β-sitosterol, lupeol, stigmasterol, campesterol, 24(25)-dihydrocycloartenol). 6-Phenyldodecane was identified by comparison of its mass spectral fragmentation with library data.
Performance Evaluation: In the unsaponifiable matter, 6-phenyldodecane (11.26%) and 6-phenyltridecane (11.12%) were the major compounds. The fixed oil (2 mL/kg) administered to ketoprofen-intoxicated rats (8 mg/kg, 7 days) significantly reduced oxidative stress: SOD and GSH increased by 56% and 82%, while MDA decreased by 44% compared to untreated ketoprofen group. Liver enzymes (AST, ALT, ALP) improved by 120%, 94%, and 24%, respectively. Urea and creatinine decreased by 103% and 110%; total protein increased by 13%. Histopathology showed preserved renal and hepatic architecture. DNA fragmentation was markedly reduced.
Conclusion: 6-Phenyldodecane, as a major hydrocarbon in P. ovata seed oil, is part of a bioactive complex that effectively ameliorates ketoprofen-induced hepatorenal toxicity, likely through synergistic antioxidant and membrane-stabilizing mechanisms.

6-Phenyldodecane as a Major Aromatic Hydrocarbon in Umbelliferous Vegetables with Antibacterial Potential

Baky, Mostafa H., et al. Scientific Reports 14.1 (2024): 10592.

6-Phenyldodecane, an alkylbenzene hydrocarbon, was identified as a major volatile component in the n-hexane extracts of four umbelliferous vegetables-parsley, dill, celery, and coriander. Its abundance varies among species, contributing to the distinctive chemical profiles and potential antibacterial activity of these culinary plants.
Extraction and Identification: Dried leaves of parsley, dill, celery, and coriander were extracted with n-hexane by cold sonication. The volatile profiles were analyzed by GC-MS (RTX-5MS column, 50-300 °C temperature program). Compounds were identified by comparison of mass spectra with NIST and Wiley libraries and retention indices against n-alkanes. Multivariate data analysis (PCA, HCA) was applied for sample discrimination.
Performance Evaluation: 6-Phenyldodecane was detected in all four vegetables, with the highest relative abundance in parsley (6.75%) and dill (5.83%), followed by celery (0.37%) and coriander (0.18%). Aromatic hydrocarbons constituted the major volatile class in all samples (47.8-64.0%). PCA loading plots revealed that 6-phenyldodecane, along with other phenyldodecane isomers, was enriched in dill, accounting for its distinct clustering. The n-hexane extracts showed moderate to strong antibacterial activity against Gram-positive bacteria (e.g., S. aureus inhibition zones 11.2-20.3 mm) and Gram-negative E. cloacae (9.5-17.2 mm), with celery and dill exhibiting the highest potency.
Conclusion: 6-Phenyldodecane is a signature volatile hydrocarbon in umbelliferous vegetables, contributing to their chemical heterogeneity and potential antibacterial properties, supporting their use as functional foods.

Custom Q&A

What is the molecular formula of 6-phenyldodecane?

The molecular formula of 6-phenyldodecane is C18H30.

What are the synonyms for 6-phenyldodecane?

The synonyms for 6-phenyldodecane are 2719-62-2, Benzene, (1-pentylheptyl)-, dodecan-6-ylbenzene, and Dodecane, 6-phenyl-.

What is the molecular weight of 6-phenyldodecane?

The molecular weight of 6-phenyldodecane is 246.4 g/mol.

When was 6-phenyldodecane created?

6-phenyldodecane was created on March 27, 2005.

When was 6-phenyldodecane last modified?

6-phenyldodecane was last modified on October 21, 2023.

What is the IUPAC name of 6-phenyldodecane?

The IUPAC name of 6-phenyldodecane is dodecan-6-ylbenzene.

What is the InChI of 6-phenyldodecane?

The InChI of 6-phenyldodecane is InChI=1S/C18H30/c1-3-5-7-10-14-17(13-9-6-4-2)18-15-11-8-12-16-18/h8,11-12,15-17H,3-7,9-10,13-14H2,1-2H3.

What is the InChIKey of 6-phenyldodecane?

The InChIKey of 6-phenyldodecane is ZYHJQFMTTFCBKH-UHFFFAOYSA-N.

What is the canonical SMILES of 6-phenyldodecane?

The canonical SMILES of 6-phenyldodecane is CCCCCC(CC1=CC=CC=C1)C1=CC=CC=C1.

What is the CAS number of 6-phenyldodecane?

The CAS number of 6-phenyldodecane is 2719-62-2.