O-(2-Azidoethyl)heptaethylene glycol serves as a versatile precursor for synthesizing oligo and poly(ethylene glycol) derivatives, which are vital components in various advanced materials and biochemical applications. This compound is particularly valuable in the assembly of dendrimers, hydrogels, and self-assembling systems, as well as serving as a molecular crosslinker and surface modifier. Its compatibility with acetylene-azide click reactions enables efficient and stable chemical linkages, facilitating the creation of strain-stiffening hydrogels, biodegradable tetra-PEG hydrogels for drug delivery, and heterobifunctional oligo(ethylene glycol) linkers for bioconjugation and targeted drug delivery. Additionally, it aids in preparing synthetic amphiphiles for pH-dependent carbon nanotube dispersions and enables selective glycoprotein detection through allosteric click-imprinting. Furthermore, O-(2-Azidoethyl)heptaethylene glycol is instrumental in forming bioactivated quantum dot micelles, enhancing the potential for novel nano-biotechnological applications.