NLRP3-IN-9

• CAS: 88039-46-7
• Catalog Number: ACM88039467
• Category: Inhibitors
• Molecular Weight: 240.68
• Molecular Formula: C12H13ClO3
• Description: NLRP3-IN-9 is an inhibitor of caspase-1 and NLRP3 ATPase activities. It acts by irreversibly trapping thiol nucleophiles, which prevents both ATP- and nigericin-triggered pyroptosis of human THP-1 cells in a time- and concentration-dependent manner.
• Synonyms: NLRP3-IN-9; NLRP3 IN 9; NLRP3IN9; INF-4E; INF 4E; INF4E
• IUPAC Name: Ethyl 2[(2-chlorophenyl)(hydroxy)methyl]acrylate
• Canonical SMILES: C=C(C(C1=CC=CC=C1Cl)O)C(OCC)=O
• InChI: InChI=1S/C12H13ClO3/c1-3-16-12(15)8(2)11(14)9-6-4-5-7-10(9)13/h4-7,11,14H,2-3H2,1H3
• InChI Key: BSRPDXCMAOIUOO-UHFFFAOYSA-N
• Solubility: Soluble in DMSO
• Appearance: Solid powder
• Shelf Life: >2 years if stored properly
• Storage: Dry, dark and at 0-4 °C for short term (days to weeks) or -20 °C for long term (months to years).
• Drug Formulation: This drug may be formulated in DMSO
• Elemental Analysis: C, 59.88; H, 5.44; Cl, 14.73; O, 19.94
• Exact Mass: 240.0553
• HS Tariff Code: 2934.99.9001
• Shipping: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
• Stock Solution Storage: 0-4 °C for short term (days to weeks), or -20 °C for long term (months).