1-Naphthohydroxamic acid

• CAS: 6953-61-3
• Catalog Number: ACM6953613
• Category: Inhibitors
• Molecular Weight: 187.19
• Molecular Formula: C₁₁H₉NO₂
• Description: 1-Naphthohydroxamic acid (Compound 2) is a potent and selective HDAC8 inhibitor with an IC50 of 14 μM. 1-Naphthohydroxamic acid is more selectively for HDAC8 than class I HDAC1 and class II HDAC6 (IC50 >100 μM). 1-Naphthohydroxamic acid does not increase global histone H4 acetylation and also does not reduce total intracellular HDAC activity.1-Naphthohydroxamic acid can induce tubulin acetylation.

Synthetic Use

Upstream Synthesis Route 1

• 879-18-5

• 6953-61-3

Reference: [1]Gao, Xi-Ai; Wang, Xian-Xue; Yan, Hao; Li, Jian; Yan, Ru-Long; Huang, Guo-Sheng
[Journal of the Indian Chemical Society, 2013, vol. 90, # 3, p. 381 - 385]

Downstream Synthesis Route 1

• 6953-61-3
• 2243-83-6

• 607-56-7
• 96963-53-0

Reference: [1]Ekstrand
[1887, p. 322]

* For details of the synthesis route, please refer to the original source to ensure accuracy.