187-1, N-WASP INHIBITOR

• CAS: 380488-27-7
• Catalog Number: ACM380488277
• Category: Inhibitors
• Molecular Weight: 1784.11
• Molecular Formula: C96H122N18O16
• Description: 187-1, N-WASP inhibitor, a 14-aa cyclic peptide, is an allosteric neural Wiskott-Aldrich syndrome protein (N-WASP) inhibitor. 187-1, N-WASP inhibitor potently inhibits actin assembly induced by phosphatidylinositol 4,5-bisphosphate (PIP2) with an IC50 of 2 μM. 187-1, N-WASP inhibitor prevents the activation of Arp2/3 complex by N-WASP by stabilizing the autoinhibited state of the protein.
• Synonyms: CYCLO(LKDFDPDFLFDPLQ)2;187-1, N-WASP INHIBITOR;N-WASP-INHIBITOR, 187-1;M.W. 1784.13 C96H122N18O16
• IUPAC Name: 187-1, N-WASP inhibitor
• Canonical SMILES: C1CC2C(=O)NC(C(=O)NC(C(=O)N3CCCC3C(=O)NC(C(=O)NC(C(=O)NC(C(=O)N4CCCC4C(=O)NC(C(=O)NC(C(=O)N5CCCC5C(=O)NC(C(=O)NC(C(=O)NC(C(=O)N2C1)CC6=CC=CC=C6)CCCCN)CCC(=O)N)CC7=CC=CC=C7)CC8=CC=CC=C8)CC9=CC=CC=C9)CCCCN)CCC(=O)N)CC1=CC=CC=C1)CC1=CC=CC=C1
• InChI Key: PHTIQAVQWWOKNF-RNEDXEELSA-N
• Appearance: Solid
• Storage: Sealed storage, away from moisture and light, under nitrogen. Powder-80°C, 2 years; -20°C, 1 year. *In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light, under nitrogen)
• Exact Mass: 1782.93000
• Shipping: Can be shipped at room temperature, where not in use may vary.