N-decylpropane-1,3-diamine

• CAS: 5538-99-8
• Catalog Number: ACM5538998
• Category: Main Products
• Molecular Weight: 214.39
• Molecular Formula: C13H30N2
• Synonyms: n-decyl-1,3-propanediamine
• Appearance: Colorless liquid

Case Study

Anti-Leishmania Activity of Lipophilic N-Alkyldiamines Such as N-Decyl-1,3-Propanediamine

da Costa, Cristiane F., et al. Biomedicine & Pharmacotherapy, 2009, 63(1), 40-42.

Researchers synthesized a group of long-chain N-monoalkylated diamines (like N-decyl-1,3-propanediamine) and two pyridinediamine derivatives and tested their anti-Leishmania effectiveness in vitro.
Key Findings
The ethylenediamine derivative 10 (N-dodecyl-1,2-ethanediamine), featuring a 12-carbon alkyl chain, demonstrated the highest antiproliferative efficacy against both L. amazonensis and L. chagasi, with IC50 values of 0.94 μM and 0.26 μM, respectively. Notably, it exhibited 7.3-fold greater activity against L. chagasi compared to the reference drug amphotericin B. Within the same series, compounds 8, 9, and 11 also displayed strong in vitro activity against L. amazonensis promastigotes (IC50 < 8 μM). Every ethylenediamine derivative except for compound 7 demonstrated effectiveness against L. chagasi promastigotes with IC50 values under 5 μM.
Among N-alkylated propanediamine derivatives, compounds 15 (N-decyl-1,3-propanediamine), 16, and 17 exhibited activity against both parasite forms, with 15 being the most potent (2.6 times more active than amphotericin B against L. chagasi; IC50 = 3.0 μM for 14). Butanediamine and hexanediamine derivatives (20 [N-dodecyl-1,4-butanediamine] and 22) displayed notable activity against L. amazonensis and exceptional efficacy against L. chagasi. Conversely, N-methyl-pyridyl derivatives 23 and 24 showed no activity at tested concentrations.

Custom Q&A

What is the molecular formula of N-Decylpropane-1,3-diamine?

The molecular formula of N-Decylpropane-1,3-diamine is C13H30N2.

What are the synonyms for N-Decylpropane-1,3-diamine?

The synonyms for N-Decylpropane-1,3-diamine are n-decyl-1,3-propanediamine and N'-decylpropane-1,3-diamine.

What is the molecular weight of N-Decylpropane-1,3-diamine?

The molecular weight of N-Decylpropane-1,3-diamine is 214.39 g/mol.

When was N-Decylpropane-1,3-diamine created?

N-Decylpropane-1,3-diamine was created on August 8, 2005.

When was N-Decylpropane-1,3-diamine modified?

N-Decylpropane-1,3-diamine was last modified on October 21, 2023.

What is the IUPAC name of N-Decylpropane-1,3-diamine?

The IUPAC name of N-Decylpropane-1,3-diamine is N'-decylpropane-1,3-diamine.

What is the InChI of N-Decylpropane-1,3-diamine?

The InChI of N-Decylpropane-1,3-diamine is InChI=1S/C13H30N2/c1-2-3-4-5-6-7-8-9-12-15-13-10-11-14/h15H,2-14H2,1H3.

What is the InChIKey of N-Decylpropane-1,3-diamine?

The InChIKey of N-Decylpropane-1,3-diamine is FHKWCXVXPHXBAC-UHFFFAOYSA-N.

What is the Canonical SMILES of N-Decylpropane-1,3-diamine?

The Canonical SMILES of N-Decylpropane-1,3-diamine is CCCCCCCCCCNCCCN.

What is the CAS number of N-Decylpropane-1,3-diamine?

The CAS number of N-Decylpropane-1,3-diamine is 5538-99-8.