MKC-3946

• CAS: 1093119-54-0
• Catalog Number: ACM1093119540
• Category: Inhibitors
• Molecular Weight: 380.46
• Molecular Formula: C21H20N2O3S
• Description: MKC3946 is a potent and soluble IRE1α inhibitor. MKC-3946 blocks XBP1 mRNA splicing and exhibits cytotoxicity against AML cells.
• Synonyms: MKC-3946; MKC 3946; MKC3946
• IUPAC Name: 2-hydroxy-6-(5-(4-methylpiperazine-1-carbonyl)thiophen-2-yl)-1-naphthaldehyde
• Canonical SMILES: O=CC1=C(C=CC2=C1C=CC(C3=CC=C(S3)C(N4CCN(CC4)C)=O)=C2)O
• InChI: InChI=1S/C21H20N2O3S/c1-22-8-10-23(11-9-22)21(26)20-7-6-19(27-20)15-2-4-16-14(12-15)3-5-18(25)17(16)13-24/h2-7,12-13,25H,8-11H2,1H3
• InChI Key: IVQVBMWPWPTSNO-UHFFFAOYSA-N
• Solubility: Soluble in DMSO
• Appearance: Solid powder
• Shelf Life: >2 years if stored properly
• Storage: Dry, dark and at 0-4 °C for short term (days to weeks) or -20 °C for long term (months to years).
• Drug Formulation: This drug may be formulated in DMSO
• Elemental Analysis: C, 66.30; H, 5.30; N, 7.36; O, 12.62; S, 8.43
• Exact Mass: 380.1195
• HS Tariff Code: 2934.99.9001
• Shipping: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
• Stock Solution Storage: 0-4 °C for short term (days to weeks), or -20 °C for long term (months).