Metoprine

• CAS: 7761-45-7
• Catalog Number: ACM7761457
• Category: Inhibitors
• Molecular Weight: 269.13
• Molecular Formula: C₁₁H₁₀Cl₂N₄
• Description: Metoprine (BW 197U) is a potent histamine N-methyltransferase (HMT) inhibitor. Metoprine, a diaminopyrimidine derivative, can cross the blood-brain barrier and increase brain histamine levels by inhibiting HMT. Metoprine is an antifolate and antitumor agent.
• Synonyms: 5-(3,4-Dichlorophenyl)-6-methyl-2,4-pyrimidinediamine; 2,4-Diamino-5-(3,4-; dichlorophenyl)-6-methylpyrimidine; 2,4-Diamino-5-(3',4'-dichlorophenyl)-; 6-methylpyrimidine; BW 197U; BW 50197; DDMP; Methodichlorophen; NSC 19494; NSC 7364; SK 5265; U 197
• IUPAC Name: 5-(3,4-dichlorophenyl)-6-methylpyrimidine-2,4-diamine
• Canonical SMILES: CC1=C(C(=NC(=N1)N)N)C2=CC(=C(C=C2)Cl)Cl
• InChI Key: VQJHOPSWBGJHQS-UHFFFAOYSA-N
• Boiling Point: 483.7ºC at 760 mmHg
• Melting Point: 275-276ºC
• Flash Point: 246.3ºC
• Density: 1.447g/cm³
• Appearance: Solid
• Storage: Powder-20°C, 3 years; 4°C, 2 years; In solvent-80°C, 6 months; -20°C, 1 month.
• Exact Mass: 268.02800
• H-Bond Acceptor: 4
• H-Bond Donor: 2
• Shipping: Can be shipped at room temperature, where not in use may vary.