Methyl-beta-cyclodextrin

• CAS: 128446-36-6
• Catalog Number: ACM128446366
• Category: Other Products
• Molecular Weight: 1331.36
• Molecular Formula: C₅₆H₉₈O₃₅
• Application: Methyl-beta-cyclodextrin serves as a versatile agent primarily used for disrupting lipid rafts through its ability to remove cholesterol from lipid membranes. As a randomly methylated derivative of the cyclic oligosaccharide β-cyclodextrin, it comprises seven D-(+)-glucopyranose units, each containing randomized hydrogen or methyl groups. This white powder not only enhances the aqueous solubility of various compounds but also facilitates detergent removal from protein-lipid-detergent ternary mixtures, aiding in the formation of 2D membrane protein crystals because of its notable solubility and affinity for the detergents commonly used in membrane protein chemistry. Furthermore, Methyl-beta-cyclodextrin has demonstrated effectiveness in reducing α-synuclein levels in membrane and detergent-insoluble fractions in B103 neuroblastoma cells, as well as in mouse brains within transgenic models of α-synucleinopathy, potentially offering valuable insights into neurodegenerative research.