CAS
3040301-46-7 Purity
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3040301-46-7 Purity
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LYG-409
CAS
3053857-55-6
Catalog Number
ACM-MG-3053857556
Category
Molecular Glues
Molecular Weight
515.44
Molecular Formula
C25H20F3N3O6
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Specification
Description
LYG-409 is an orally active degrader of GSPT1. LYG-409 shows excellent anti-acute myeloid leukemia and prostate cancer in vivo with TGI of 94.34% and 104.49%, respectively.
IUPAC Name
N-[[2-(2,6-dioxopiperidin-3-yl)-1-oxo-3H-isoindol-5-yl]methyl]-6-(trifluoromethoxy)-2H-chromene-3-carboxamide
SMILES
O=C1N(CC2=C1C=CC(CNC(C3=CC4=C(OC3)C=CC(OC(F)(F)F)=C4)=O)=C2)C5CCC(NC5=O)=O
InChI
InChI=1S/C25H20F3N3O6/c26-25(27,28)37-17-2-5-20-14(9-17)8-16(12-36-20)22(33)29-10-13-1-3-18-15(7-13)11-31(24(18)35)19-4-6-21(32)30-23(19)34/h1-3,5,7-9,19H,4,6,10-12H2,(H,29,33)(H,30,32,34)
InChI Key
BYWKZOLIKCQOGA-UHFFFAOYSA-N
Appearance
White to off-white solid
Shipping
Generally, shipped at room temperature in continental US; may vary elsewhere.
Storage Conditions
Store at -20 °C
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