CAS
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Lenalidomide sodium
Catalog Number
ACM-MG-00029
Category
Molecular Glues
Molecular Weight
281.24
Molecular Formula
C13H12N3NaO3
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Specification
Description
Lenalidomide (sodium), a Thalidomide derivative, serves as a molecular glue and an orally active immunomodulator. It acts as a cereblon (CRBN) ligand and triggers selective ubiquitination and subsequent degradation of the lymphoid transcription factors IKZF1 and IKZF3 via the CRBN-CRL4 ubiquitin ligase. Echoing its specificity, Lenalidomide (sodium) inhibits the proliferation of mature B-cell lymphomas, notably multiple myeloma, and promotes IL-2 secretion from T cells.
Synonyms
CC-5013 sodium
IUPAC Name
sodium;3-(7-amino-3-oxo-1H-isoindol-2-yl)piperidin-1-ide-2,6-dione
SMILES
C1CC(=O)[N-]C(=O)C1N2CC3=C(C2=O)C=CC=C3N.[Na+]
InChI
InChI=1S/C13H13N3O3.Na/c14-9-3-1-2-7-8(9)6-16(13(7)19)10-4-5-11(17)15-12(10)18;/h1-3,10H,4-6,14H2,(H,15,17,18);/q;+1/p-1
InChI Key
CHIQJJOPHHFACL-UHFFFAOYSA-M
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