LC3-mHTT-IN-AN2

• CAS: 7758-73-8
• Catalog Number: ACM-MG-7758738
• Category: Molecular Glues
• Molecular Weight: 254.24
• Molecular Formula: C15H10O4
• Description: Compound AN2 reduces mHTT levels through autophagic degradation by interacting with both the autophagosome protein microtubule-associated protein 1A/1B light chain 3 (LC3)1 and mutant huntingtin protein (mHTT). AN2 reduces the levels of mHTT in an allele-selective manner in cultured Huntington disease (HD) mouse neurons.
• Synonyms: 5,7-dihydroxy-4-phenylcoumarin
• IUPAC Name: 5,7-dihydroxy-4-phenylchromen-2-one
• SMILES: OC1=CC(O)=C2C(OC(=O)C=C2C2=CC=CC=C2)=C1
• InChI: InChI=1S/C15H10O4/c16-10-6-12(17)15-11(9-4-2-1-3-5-9)8-14(18)19-13(15)7-10/h1-8,16-17H
• InChI Key: HUQKUJNSVHEHIH-UHFFFAOYSA-N
• Solubility: Soluble in DMSO, DMF
• Appearance: White solid
• EC Number: 622-107-7
• Shipping: Room temperature
• Storage Conditions: Refrigerated