LC3-mHTT-IN-AN1

• CAS: 486443-73-6
• Catalog Number: ACM-MG-486443736
• Category: Molecular Glues
• Molecular Weight: 411.05
• Molecular Formula: C15H9Br2NO3
• Description: Compound AN1 reduces mHTT levels through autophagic degradation by interacting with both the autophagosome protein microtubule-associated protein 1A/1B light chain 3 (LC3)1 and mutant huntingtin protein (mHTT). AN1 reduces the levels of mHTT in an allele-selective manner in cultured Huntington disease (HD) mouse neurons.
• Synonyms: LC3-mHTT-IN-1
• IUPAC Name: (3Z)-5-bromo-3-[(3-bromo-4,5-dihydroxyphenyl)methylidene]-1H-indol-2-one
• SMILES: OC1=C(O)C(Br)=CC(\C=C2/C(=O)NC3=C2C=C(Br)C=C3)=C1
• InChI: InChI=1S/C15H9Br2NO3/c16-8-1-2-12-9(6-8)10(15(21)18-12)3-7-4-11(17)14(20)13(19)5-7/h1-6,19-20H,(H,18,21)/b10-3-
• InChI Key: GPKLWRHHVIBYEO-KMKOMSMNSA-N
• Solubility: Soluble in DMSO, DMF
• Appearance: White solid
• Shipping: Room temperature
• Storage Conditions: Refrigerated