Description
L-Histidine is a proteinogenic amino acid and an essential amino acid required for histamine production. This positively charged amino acid is vital for growth, tissue repair, myelin sheath maintenance, and histamine synthesis. Histamine plays critical roles in immunity, gastric secretion, and more. L-Histidine is essential for blood cell production and tissue protection against radiation and heavy metals. L-Histidine plays a role as a metabolite and also acts as a cofactor in enzyme protection during protein synthesis. It is an L-enantiomer of histidine and is necessary for histamine synthesis and human development. L-Histidine finds applications in cell culture, metabolomics and biochemical research.
Synonyms
(S)-2-Amino-3-(4-imidazolyl)propionic acid, NSC 137773
Molecular Formula
C6H9N3O2
Canonical SMILES
N[C@@H](Cc1c[nH]cn1)C(O)=O
InChI
1S/C6H9N3O2/c7-5(6(10)11)1-4-2-8-3-9-4/h2-3,5H,1,7H2,(H,8,9)(H,10,11)/t5-/m0/s1
InChI Key
HNDVDQJCIGZPNO-YFKPBYRVSA-N
Boiling Point
458.9±35.0 ℃at 760 mmHg
Melting Point
282 ℃(dec.) (lit.)
Application
L-histidine has been used as a component in agar plates containing 5-fluorocytosine (5-FC) for the selection of yeast transformants. It has also been used as a component of adult mouse keratinocyte growth medium.
Biochem Physiol Actions
L-Histidine is an essential amino acid that binds to metal ions and may aid in the transport of copper. Histidine is widely present at the active sites of enzymes. It also has a role in binding of heme groups, macromolecules and phosphate groups in the binding sites of proteins.
Biological Source
non-animal source
Feature
Can be used in Metabolomics and Biochemical research
High-quality compound suitable for multiple research applications
Gene Information
human CA1(759), CA2(760)
Impurities
endotoxin, tested
Technique
cell culture | mammalian: suitable
Vapor Pressure
0.0±1.2 mmHg at 25℃
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