Product Name
L-Aspartic acid
Category
Heterocyclic Organic Compound
Description
Aspartic acid (abbreviated as Asp or D; encoded by the codons [GAU and GAC]), also known as aspartate, is an α-amino acid that is used in the biosynthesis of proteins. It contains an α-amino group (which is in the protonated −NH+ 3 form under biological conditions), an α-carboxylic acid group (which is in the deprotonated −COO− form under biological conditions), and a side chain CH2COOH. Under physiological conditions in proteins the sidechain usually occurs as the negatively charged aspartate form, −COO−. It is semi-essential in humans, meaning the body can synthesize it from oxaloacetate.In proteins aspartate sidechains are often hydrogen bonded, often as asx turns or asx motifs, which often occur at the N-termini of alpha helices.Asp’s L-isomer is one of the 23 proteinogenic amino acids, i.e., the building blocks of proteins. Asp (and glutamic acid) is classified as acidic, with a pKa of 3.9, however in a peptide this is highly dependent on the local environment (as with all amino acids), and could be as high as 14. Asp is pervasive in biosynthesis.L-aspartic acid is one of the two main ingredients of the artificial sweetener aspartame, along with L-phenylalanine.
Synonyms
(S)-Butanedioicaci
IUPAC Name
(2S)-2-Aminobutanedioic acid
Canonical SMILES
C(C(C(=O)O)N)C(=O)O
InChI
InChI=1S/C4H7NO4/c5-2(4(8)9)1-3(6)7/h2H,1,5H2,(H,6,7)(H,8,9)/t2-/m0/s1
InChI Key
CKLJMWTZIZZHCS-REOHCLBHSA-N
Melting Point
>300 °C(lit.)
Solubility
Slightly soluble in water, insoluble in ether
Storage
Store below +30 °C
Isomeric SMILES
C([C@@H](C(=O)O)N)C(=O)O
Monoisotopic Mass
133.03750770
pH
2.5-3.5 (4g/l, H₂O, 20°C)
Safety Description
26-24/25-22-36
Stability
Stable. Combustible. Incompatible with strong oxidising agents.
Storage Conditions
Below +30 °C
Topological Polar Surface Area
101 Ų
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