CAS
2892065-45-9 Purity
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2892065-45-9 Purity
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JP-2-196 alkyne
CAS
2901113-25-3
Catalog Number
ACM-MG-2901113253
Category
Molecular Glues
Molecular Weight
312.37
Molecular Formula
C18H20N2O3
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Specification
Description
JP-2-196 alkyne is a covalent RNF126 chemical handle that binds to several other RING E3 ubiquitin ligases including RNF14, RNF40, RNF219, MID2, and LRSAM1. By facilitating E3 ligase recruitment, JP-2-196 alkyne induces proteasomal degradation of diverse target proteins.
IUPAC Name
(E)-1-(4-methoxyphenyl)-4-(4-prop-2-ynylpiperazin-1-yl)but-2-ene-1,4-dione
SMILES
O=C(C1=CC=C(C=C1)OC)/C=C/C(N2CCN(CC2)CC#C)=O
InChI
InChI=1S/C18H20N2O3/c1-3-10-19-11-13-20(14-12-19)18(22)9-8-17(21)15-4-6-16(23-2)7-5-15/h1,4-9H,10-14H2,2H3/b9-8+
InChI Key
COPXSSDNGLPYDY-CMDGGOBGSA-N
Solubility
Soluble in DMSO
Storage Conditions
Store at -20 °C
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