Isopropyl Myristate

• CAS: 110-27-0
• Catalog Number: ACM110270
• Category: Main Products
• Molecular Weight: 270.5
• Molecular Formula: C17H34O2
• Description: Ester of isopropyl alcohol and myristic acid (vegetable-derived). Low viscosity fluid non-greasy emollient, tolerates wide pH range, compatible with most surfactants. Thanks to its low viscosity and density, it has a high spreadability. Specific gravity 0.85 (at 20°C).
• Synonyms: 1-Methylethyl tetradecanoate
• IUPAC Name: Propan-2-yl tetradecanoate
• Canonical SMILES: CCCCCCCCCCCCCC(=O)OC(C)C
• InChI: InChI=1S/C17H34O2/c1-4-5-6-7-8-9-10-11-12-13-14-15-17(18)19-16(2)3/h16H,4-15H2,1-3H3
• InChI Key: AXISYYRBXTVTFY-UHFFFAOYSA-N
• Boiling Point: 193 °C
• Melting Point: 3 °C
• Flash Point: >230 °F
• Density: 0.85 g/mL at 25 °C(lit.)
• Solubility: Water-insoluble, but soluble with silicones, and hydrocarbons
• Appearance: Colorless oil-like liquid, odorless
• Application: Creams, lotions, hand creams, shampoo, shower gels, makeup removers, powders and foundations.
• Storage: Store in a closed container at a dry place at room temperature
• Alpha Sort: Isopropyl myristate
• Complexity: 199
• Composition: Isopropyl myristate
• Covalently-Bonded Unit Count: 1
• Defined Atom Stereocenter Count: 0
• EC Number: 203-751-4
• Exact Mass: 270.255880323
• Features And Benefits: Superior emollient for non-greasy bath, body and baby oilsLubricant and compression aid for pressed powdersLight & non-tacky emollient for creams and lotions. Readily adsorbed by the skinWhen used at high concentrations it gently lifts makeup and surface dirtGives gloss and shine to hairResistant to oxidation (does not become rancid)Widely used as diluent for fragrance oils.
• Hazard Codes: Xi
• Hazard Statements: Xi:Irritant
• Heavy Atom Count: 19
• HS Code: 2712900000
• Hydrogen Bond Acceptor Count: 2
• Hydrogen Bond Donor Count: 0
• LogP: 5.63910
• MDL Number: MFCD00008982
• Monoisotopic Mass: 270.255880323
• Odor: Practically odorless
• Packing Group: I; II; III
• Physical State: Liquid
• PSA: 26.3
• Refractive Index: n20/D 1.434(lit.)
• Rotatable Bond Count: 14
• Safety Description: S26-S36
• Stability: Stable. Combustible. Incompatible with strong oxidizing agents.
• Storage Conditions: 2-8 °C
• Topological Polar Surface Area: 26.3 Ų
• Vapor Pressure: 0.000329mmHg at 25°C
• Viscosity: 4.8cp (25°C)
• WGK Germany: –

Case Study

Reactive Distillation Design for Production of Isopropyl Myristate

Pushkala, S. Purna, et al. Cleaner Chemical Engineering, 2023, 5, 100090.

Isopropyl myristate (IPM) can be produced by esterification of myristic acid and isopropyl alcohol in a reactive distillation column. In order to realize the IPM production process with high purity and high conversion rate, the reactive distillation tower and IMC-PID controller were designed using the IMC-PID-Laurent tuning method.
Production process of isopropyl myristate
· The feeds [isopropyl alcohol (IPA) and myristic acid (MA)] are fed into the reaction tower, and an esterification reaction occurs between IPA and MA in the liquid phase.
· The production design of IPM is based on azeotropic reaction distillation of entrainer. In such processes, an entrainer (cyclohexane) is added to remove water, preventing the formation of an azeotrope and thereby shifting the equilibrium forward.
· The optimal operating conditions for a reactive distillation column used to produce IPM include column pressure of 1 atm, universal gas constant of 8.3144 L bar/mol K, chemical equilibrium constant of 2, reflux of 1.99 Cal/K.mol, reboiler duty of 0.99 kJ/s, fresh liquid/vapor feed of flow rate of 12.6 mole/s, and distillate/bottom flow rate of 12.6mole fraction, etc.

Formation of Surfactant Mixed Microemulsion Using Isopropyl Myristate as Oil

Soumik Bardhan, et al. Journal of colloid and interface science, 2014, 430, 129-139.

This work reports a mixed surfactant-derived microemulsion system based on isopropyl myristate (IPM) polar lipophilic oil. In this system, a mixed surfactant microenvironment consists of cationic (cetyltrimethylammonium bromide, CTAB) and nonionic (Brij-35) stabilized in 1-pentanol (Pn) and IPM.
Construction of pseudo ternary phase diagram of microemulsions
· A pseudo-ternary phase diagram was created to determine the concentration range at which microemulsions are formed by the components (oil/water/surfactant and/or cosurfactant). This diagram was constructed using the titrimetric method at room temperature.
· A mixture of oil (IPM) and surfactant (CTAB and Brij-35) was prepared with varying weight percentages, while maintaining a 1:2 ratio of surfactant to cosurfactant (Pn). The mixture was then slowly titrated with water under gentle magnetic stirring and sonicated for 10 minutes.
· Samples were classified as microemulsions if they appeared as clear, transparent, and translucent liquids, and were left overnight to ensure no phase separation occurred. After equilibration, the systems were visually assessed, with the accuracy of the phase boundaries being within 4 wt%.

Custom Q&A

What is the CAS number of Isopropyl Myristate?

The CAS number of Isopropyl Myristate is 110-27-0.

What is the molecular weight of Isopropyl Myristate?

The molecular weight of Isopropyl Myristate is 270.5.

What is the molecular formula of Isopropyl Myristate?

The molecular formula of Isopropyl Myristate is C17H34O2.

What are the synonyms of Isopropyl Myristate?

The synonyms of Isopropyl Myristate are 1-Methylethyl tetradecanoate and Propan-2-yl tetradecanoate.

What is the boiling point of Isopropyl Myristate?

The boiling point of Isopropyl Myristate is 193 °C.

What is the melting point of Isopropyl Myristate?

The melting point of Isopropyl Myristate is 3 °C.

What is the purity of Isopropyl Myristate?

The purity of Isopropyl Myristate is 95%+.

What is the density of Isopropyl Myristate at 25 °C?

The density of Isopropyl Myristate at 25 °C is 0.85 g/mL.

What are the typical applications of Isopropyl Myristate?

The typical applications of Isopropyl Myristate include use as a dispersing agent, emulsion stabilizer, lubricant, and plasticizer.

In what physical state is Isopropyl Myristate?

Isopropyl Myristate is in a liquid physical state.

Synthetic Use

Upstream Synthesis Route 1

• 67-63-0
• 112-64-1

• 110-27-0

Reference: [1]Althouse et al.
[Journal of the American Oil Chemists' Society, 1947, vol. 24, p. 257]

Downstream Synthesis Route 1

• 110-27-0

• 544-63-8

Reference: [1]Node, Manabu; Nishide, Kiyoharu; Sai, Midori; Fuji, Kaoru; Fujita, Eiichi
[Journal of Organic Chemistry, 1981, vol. 46, # 10, p. 1991 - 1993]
[2]Theodorou, Vassiliki; Skobridis, Konstantinos; Tzakos, Andreas G.; Ragoussis, Valentine
[Tetrahedron Letters, 2007, vol. 48, # 46, p. 8230 - 8233]

* For details of the synthesis route, please refer to the original source to ensure accuracy.