CAS
121-25-5 Purity
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121-25-5 Purity
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Intoplicine
CAS
125974-72-3
Catalog Number
ACM125974723
Category
Inhibitors
Molecular Weight
348.44
Molecular Formula
C21H24N4O
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Specification
Description
Intoplicine (RP 60475), an antitumor derivative in the 7H-benzo[e]pyrido[4,3-b]indole series, is a DNA topoisomerase I and II inhibitor. Intoplicine strongly binds DNA (KA = 2 x 105 /M) and thereby increases the length of linear DNA.
Synonyms
11-((3-(Dimethylamino)propyl)amino)-8-methyl-7H-benzo(e)pyrido(4,3-b)indol-3-ol; UNII-FB2CIN6HMI;
IUPAC Name
Intoplicine
Canonical SMILES
CC1=CN=C(C2=C1NC3=C2C4=C(C=C3)C=C(C=C4)O)NCCCN(C)C
InChI Key
QROONAIPJKQFMC-UHFFFAOYSA-N
Boiling Point
635.5ºC at 760mmHg
Flash Point
338.2ºC
Density
1.286g/cm³
Exact Mass
348.19500
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