Hydroxyapatite

• CAS: 1306-06-5
• Catalog Number: ALC-FP-1306065
• Category: Featured Products
• Appearance: Powder
• Particle Size: 200nm

Case Study

Hydroxyapatite-Based Metal and Metal Oxide Nanocomposites for Environmental Applications

Fatimah I, et al. Inorganic Chemistry Communications, 2026, 183, 15878.

This case study examines the experimental synthesis of metal- and metal oxide-modified hydroxyapatite (HAp) nanocomposites for environmental remediation. HAp was employed as a functional inorganic scaffold due to its high surface area, ion-exchange capacity, and structural stability. Two preparation strategies were systematically applied: in situ nanocomposite formation and post-synthesis modification. In the in situ approach, metal precursors (e.g., Mg²⁺) were introduced during the sol-gel synthesis of HAp, enabling simultaneous nucleation of MgO within the HAp matrix. Alternatively, post-synthesis methods involved the physical or chemical deposition of preformed metal oxide nanoparticles (e.g., CuO) onto synthesized HAp. Phase formation and dispersion were confirmed by XRD and SEM analyses. The experimental design demonstrates that precise control of dopant type and synthesis route allows tailoring of catalytic, adsorptive, and photocatalytic properties, validating hydroxyapatite nanocomposites as versatile materials for environmental applications.

Hydroxyapatite-Loaded Iron Alginate Beads for ³²P Carrier Applications

Chernykh IN, et al. International Journal of Biological Macromolecules, 2025, 334, 149222.

This case study focuses on the experimental development of hydroxyapatite (HAp)-loaded iron alginate beads as carriers for radioactive phosphorus (^32P). Beads were synthesized via ionic crosslinking by dropwise addition of sodium alginate solutions into FeCl₃ crosslinker solutions under controlled stirring. For composite formation, hydroxyapatite suspensions were homogeneously mixed with alginate prior to gelation, yielding mineralized beads with enhanced phosphate affinity. Phosphate and ^32P loading was achieved through sorption from aqueous solutions, exploiting HAp-driven calcium-phosphate interactions and isotope exchange mechanisms. Sorption kinetics and capacity were quantified using spectrophotometry and liquid scintillation counting. The incorporation of hydroxyapatite significantly improved phosphate uptake rates and radionuclide retention in saline and serum-mimicking media. These results experimentally demonstrate hydroxyapatite's critical role in improving loading efficiency and long-term stability of radionuclide delivery systems.