Structure

HuR degrader 2

CAS
3040301-46-7
Catalog Number
ACM-MG-3040301467
Category
Molecular Glues
Molecular Weight
345.35
Molecular Formula
C20H15N3O3

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Specification

Description
HuR degrader 2 (Compound 3) is a molecule glue, which targets RNA-binding protein Hu antigen R (HuR) and degrades 30% HuR at 0.1 μM. HuR degrader 2 inhibits the proliferation of cancer cell Colo-205, with IC50≤200 nM.
SMILES
O=C1NC(C(C2=COC3=C2C=CC(C4=C(C=CN5)C5=NC=C4)=C3)CC1)=O
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