CAS
3050683-29-6 Purity
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3050683-29-6 Purity
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HGC652
CAS
3055558-98-7
Catalog Number
ACM-MG-3055558987
Category
Molecular Glues
Molecular Weight
449.60
Molecular Formula
C23H28FNO3S2
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Specification
Description
HGC652 is the molecular glue, that targets E3 ubiquitin ligase TRIM21, promotes the formation of a ternary complex between TRIM21 and NUP98, induces degradation of NUP155 and nuclear pore complex proteins, thereby causing the cell death. HGC652 inhibits the proliferation of multi cancer cells, according to the expression level of TRIM21.
IUPAC Name
N-(cyclohexylmethyl)-4-(4-fluoro-2-methylsulfanylphenyl)-N-methyl-2-methylsulfonylbenzamide
SMILES
CN(C(C1=CC=C(C2=C(SC)C=C(F)C=C2)C=C1S(=O)(C)=O)=O)CC3CCCCC3
InChI
InChI=1S/C23H28FNO3S2/c1-25(15-16-7-5-4-6-8-16)23(26)20-11-9-17(13-22(20)30(3,27)28)19-12-10-18(24)14-21(19)29-2/h9-14,16H,4-8,15H2,1-3H3
InChI Key
MEFAYSLODGHXPL-UHFFFAOYSA-N
Appearance
White to off-white solid
Shipping
Generally, shipped at room temperature in continental US; may vary elsewhere.
Storage Conditions
Store at -20 °C
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