CAS
2631059-94-2 Purity
≥95%
2631059-94-2 Purity
≥95%
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HbF inducer 2
CAS
2654011-51-3
Catalog Number
ACM-MG-2654011513
Category
Molecular Glues
Molecular Weight
385.46
Molecular Formula
C21H27N3O4
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Specification
Description
HbF inducer 3 (Compound dWIZ-2) is an orally active molecular glue, which degrades the WIZ transcription factor (DC50=13 nM in primary human erythroid precursor cell) and induces the expression of fetal hemoglobin (HbF) (EC50=100 nM). HbF inducer 3 exhibits good pharmacokinetic characteristics in cynomolgus monkeys.
IUPAC Name
3-[6-[[(2R)-1-ethylpiperidin-2-yl]methoxy]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione
SMILES
O=C(C(N(CC1=C2C=CC(OC[C@@H]3N(CC)CCCC3)=C1)C2=O)CC4)NC4=O
InChI
InChI=1S/C21H27N3O4/c1-2-23-10-4-3-5-15(23)13-28-16-6-7-17-14(11-16)12-24(21(17)27)18-8-9-19(25)22-20(18)26/h6-7,11,15,18H,2-5,8-10,12-13H2,1H3,(H,22,25,26)/t15-,18?/m1/s1
InChI Key
DHFJHVJOMHNTSK-NNJIEVJOSA-N
Shipping
Generally, shipped at room temperature in continental US; may vary elsewhere.
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