GW5074

• CAS: 220904-83-6
• Catalog Number: ACM-MG-220904836
• Category: Molecular Glues
• Molecular Weight: 520.95
• Molecular Formula: C15H8Br2INO2
• Description: GW5074 reduces mHTT levels through autophagic degradation by interacting with both the autophagosome protein microtubule-associated protein 1A/1B light chain 3 (LC3)1 and mutant huntingtin protein (mHTT). It is also a potent and selective c-Raf inhibitor with IC50 of 9 nM.
• Synonyms: 5-Iodo-3-[(3,5-dibromo-4-hydroxyphenyl)methylene]-2-indolinone
• IUPAC Name: (3Z)-3-[(3,5-dibromo-4-hydroxyphenyl)methylidene]-5-iodo-1H-indol-2-one
• SMILES: OC1=C(Br)C=C(\C=C2/C(=O)NC3=C2C=C(I)C=C3)C=C1Br
• InChI: InChI=1S/C15H8Br2INO2/c16-11-4-7(5-12(17)14(11)20)3-10-9-6-8(18)1-2-13(9)19-15(10)21/h1-6,20H,(H,19,21)/b10-3-
• InChI Key: LMXYVLFTZRPNRV-KMKOMSMNSA-N
• Solubility: Soluble in DMSO, DMF
• Appearance: White solid
• Shipping: Room temperature
• Storage Conditions: Refrigerated