girinimbine

• CAS: 23095-44-5
• Catalog Number: ACM23095445-1
• Category: Main Products
• Molecular Weight: 263.3
• Molecular Formula: C18H17NO
• Synonyms: 3,11-Dihydro-3,3,5-trimethylpyrano[3,2-a]carbazole
• InChI: InChI=1S/C18H17NO/c1-11-10-14-12-6-4-5-7-15(12)19-16(14)13-8-9-18(2,3)20-17(11)13/h4-10,19H,1-3H3
• InChI Key: GAEQWKVGMHUUKO-UHFFFAOYSA-N
• Melting Point: 176 °C
• Complexity: 416
• Covalently-Bonded Unit Count: 1
• Defined Atom Stereocenter Count: 0
• Exact Mass: 263.131014166
• Heavy Atom Count: 20
• Hydrogen Bond Acceptor Count: 1
• Hydrogen Bond Donor Count: 1
• Monoisotopic Mass: 263.131014166
• Physical State: Powder
• Rotatable Bond Count: 0
• Topological Polar Surface Area: 25 Ų

Case Study

Girinimbine-Induced Oxidative Stress for Apoptosis in HepG2 Cells

Syam S, et al. PharmaNutrition, 2014, 2(3), 92.

Girinimbine has been experimentally applied in hepatocellular carcinoma studies to elucidate its apoptotic mechanisms. In vitro assays using HepG2 cells revealed that treatment with girinimbine led to a marked increase in intracellular reactive oxygen species (ROS), followed by depletion of glutathione (GSH), induction of heat shock proteins (Hsp-70 and -90), DNA damage, and mitochondrial membrane potential (MMP) collapse. Methodologically, apoptosis was monitored through ROS-sensitive fluorescent probes, GSH quantification assays, and mitochondrial potential analysis, with catalase and ascorbic acid employed as protective controls to confirm oxidative stress dependence. The depletion of GSH heightened cellular susceptibility to apoptosis, while antioxidant supplementation attenuated girinimbine's effects, demonstrating a ROS-mediated pathway. This experimental framework highlights girinimbine's potential as a dietary-derived anticancer compound, providing mechanistic evidence for its application in hepatocellular carcinoma prevention and therapeutic strategies.

Custom Q&A

What is the chemical formula of girinimbine?

The chemical formula of girinimbine is C18H17NO.

What is the molecular weight of girinimbine?

The molecular weight of girinimbine is 263.33.

What is the melting point of girinimbine?

The melting point of girinimbine is 176 °C.

What are some of the biological effects of girinimbine?

Girinimbine has antibacterial, anti-inflammatory, antioxidant, and antitumor activities.

What is the predicted boiling point of girinimbine?

The predicted boiling point of girinimbine is 450.0±34.0 °C.

How is girinimbine synthesized?

Girinimbine is a natural product found in Clausena harmandiana.

What is the predicted density of girinimbine?

The predicted density of girinimbine is 1.187±0.06 g/cm3.

What is the pKa value of girinimbine?

The pKa value of girinimbine is 17.31±0.40.

What are some synonyms for girinimbine?

Some synonyms for girinimbine are 3,11-Dihydro-3,3,5-trimethylpyrano[3,2-a]carbazole and Pyrano[3,2-a]carbazole, 3,11-dihydro-3,3,5-trimethyl-.

What are some of the applications of girinimbine?

Girinimbine can induce apoptosis and has various biological effects, making it useful for antibacterial, anti-inflammatory, antioxidant, and antitumor activities.