Catalog Number
ACM175291562-2
Product Name
Fmoc-Thr(PO(OBzl)OH)-OH
Description
An excellent building block for the preparation of phosphothreonine-containing peptides by Fmoc SPPS. This derivative can be introduced using standard activation methods, such as PyBOPand TBTU. The monoprotected phosphothreonine residue once incorporated is stable to piperidine. Using this reagent, even peptides containing multiple phosphorylation sites can be prepared efficiently by standard Fmoc SPPS methods.A paper describes the use of this derivative in the preparation of phospholamban , a 52 residue peptide containing both phosphoserine and phosphothreonine.
Synonyms
Fmoc-Thr(PO(OBzl)OH)-OH, N-α-Fmoc-O-benzyl-L-phosphothreonine
Molecular Formula
C26H26NO8P
InChI
1S/C26H26NO8P/c1-17(35-36(31,32)34-15-18-9-3-2-4-10-18)24(25(28)29)27-26(30)33-16-23-21-13-7-5-11-19(21)20-12-6-8-14-22(20)23/h2-14,17,23-24H,15-16H2,1H3,(H,27,30)(H,28,29)(H,31,32)/t17-,24+/m0/s1
InChI Key
HOFDVXHILSPFNS-BXKMTCNYSA-N
Application
Peptide synthesis.
Assay
≥90.0% (acidimetric)
≥98% (TLC)
≥98.0% (HPLC)
Reaction Suitability
reaction type: Fmoc solid-phase peptide synthesis
Storage Temperature
15-25℃
Type
Unusual Amino Acids, Analogs of Serine, Threonine, and Statine