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Description
Introduction of 4-sulfo-phenylalanine is an effective strategy for increasing solubility of a peptide. This amino acid has also been employed in analogs of angiotensin 2 , phytosulfokine , and cyclolinopeptide A. Its incorporation during solid phase synthesis using Fmoc-Phe(SO3Na)-OH is best carried out with base-mediated coupling methods such as PyBOPor HBTU.
Synonyms
Fmoc-Phe(SO3Na)-OH, N-α-Fmoc-4-sulfophenylalanine sodium salt