Fmoc-Glu(OtBu)-OH

• CAS: 71989-18-9
• Catalog Number: ACM71989189-1
• Category: Amino Acids
• Molecular Weight: 425.47
• Molecular Formula: C24H27NO6
• Description: High purity Fmoc-protected amino acid for research and process production of peptides, with very low levels of dipeptide, free-amino acids and acetic acid impurities.; Standard building block for introduction of glutamic acid amino-acid residues by Fmoc SPPS.
• Synonyms: Fmoc-Glu(OtBu)-OH, N-α-Fmoc-L-glutamic acid γ-t.-butyl ester
• InChI: 1S/C24H27NO6/c1-24(2,3)31-22(28)20(12-13-21(26)27)25-23(29)30-14-19-17-10-6-4-8-15(17)16-9-5-7-11-18(16)19/h4-11,19-20H,12-14H2,1-3H3,(H,25,29)(H,26,27)
• InChI Key: GOPWHXPXSPIIQZ-UHFFFAOYSA-N
• Melting Point: 80-95℃
• Application: Peptide synthesis.
• Assay: ≥95.0% (acidimetric); ≥98% (TLC); ≥99.0% (HPLC)
• Form: powder
• Functional Group: carboxylic acid
• MDL Number: MFCD00037135
• Quality Level: 400
• Reaction Suitability: reaction type: Fmoc solid-phase peptide synthesis
• Storage Temperature: 2-30℃
• Type: Unlabeled Standard Amino Acids, Glutamic Acid (Glu)

Synthetic Use

Upstream Synthesis Route 1

• 56-86-0
• 102774-86-7
• 115-11-7

• 84793-07-7
• 71989-18-9
• 129460-14-6

Reference: [1] Synthesis, 1990, # 7, p. 571 - 572

Downstream Synthesis Route 1

• 71989-18-9

• 2419-56-9

Reference: [1] Patent: WO2011/19942, 2011, A2, . Location in patent: Page/Page column 31-32

Downstream Synthesis Route 2

• 71989-18-9

• 56-86-0
• 2419-56-9

Reference: [1] Amino Acids, 2014, vol. 46, # 2, p. 367 - 374

* For details of the synthesis route, please refer to the original source to ensure accuracy.