Fmoc-Asp(OtBu)-OH

• CAS: 71989-14-5
• Catalog Number: ACM71989145-1
• Category: Amino Acids
• Molecular Weight: 411.45
• Molecular Formula: C23H25NO6
• Description: High purity Fmoc-protected amino acid for research and process production of peptides, with very low levels of dipeptide, free-amino acids and acetic acid impurities.; Standard building block for introduction of aspartic acid amino-acid residues by Fmoc SPPS.
• Synonyms: Fmoc-Asp(OtBu)-OH, N-α-Fmoc-L-aspartic acid β-t.-butyl ester
• InChI: 1S/C23H25NO6/c1-23(2,3)30-20(25)12-19(21(26)27)24-22(28)29-13-18-16-10-6-4-8-14(16)15-9-5-7-11-17(15)18/h4-11,18-19H,12-13H2,1-3H3,(H,24,28)(H,26,27)/p-1/t19-/m0/s1
• InChI Key: FODJWPHPWBKDON-IBGZPJMESA-M
• Melting Point: 143-150℃
• Application: Peptide synthesis.
• Assay: ≥98% (TLC); ≥98.0% (acidimetric); ≥99.0% (HPLC)
• Form: powder
• Functional Group: carboxylic acid
• MDL Number: MFCD00037131
• Quality Level: 400
• Reaction Suitability: reaction type: Fmoc solid-phase peptide synthesis
• Storage Temperature: 2-30℃
• Type: Unlabeled Standard Amino Acids, Aspartic Acid (Asp)

Synthetic Use

Upstream Synthesis Route 1

• 144120-52-5

• 71989-14-5

Reference: [1] Synlett, 2014, vol. 25, # 16, p. 2319 - 2322

Upstream Synthesis Route 2

• 82911-69-1
• 3057-74-7

• 71989-14-5

Reference: [1] Synthetic Communications, 2009, vol. 39, # 11, p. 2022 - 2031
[2] Chemical and Pharmaceutical Bulletin, 1996, vol. 44, # 11, p. 2189 - 2191

Downstream Synthesis Route 1

• 71989-14-5

• 136083-57-3

Reference: [1] Chemistry - A European Journal, 2015, vol. 21, # 31, p. 11014 - 11016
[2] Journal of Peptide Science, 2010, vol. 16, # 3, p. 159 - 164
[3] Organic Letters, 2012, vol. 14, # 24, p. 6346 - 6349

Downstream Synthesis Route 2

• 20866-48-2
• 35661-40-6
• 71989-14-5
• 125238-99-5

• 110116-75-1

Reference: [1]Journal of Medicinal Chemistry,1987,vol. 30,p. 2094 - 2099

* For details of the synthesis route, please refer to the original source to ensure accuracy.